Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

Background The highly complex pathogenesis of Type 1 Diabetes is driven by several
immune cell types with both effector and regulatory characteristics, which ultimately ends in …

Summary Type 1 diabetes (T1D) develops when there are insufficient insulin-producing beta
cells to maintain glucose homeostasis. The prevailing view has been that T1D is caused by …

Summary Recent studies in Type 1 Diabetes (T1D) support an emerging model of disease
pathogenesis that involves intrinsic β-cell fragility combined with defects in both innate and …

Type 1 diabetes results from the poorly understood process of islet autoimmunity, which
ultimately leads to the loss of functional pancreatic beta cells. Mounting evidence supports …

The destruction of beta cells in type 1 diabetes in humans and in autoimmune diabetes in
the NOD mouse model is a consequence of chronic islet inflammation in the pancreas. The …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Type 1 diabetes (T1D) is characterized by the unresolved autoimmune inflammation and
islet β cell destruction. The islet resident antigen-presenting cells (APCs) including dendritic …

Type 1 diabetes (T1D) is a chronic metabolic disease characterized by insulin deficiency,
generally resulting from progressive autoimmune-mediated destruction of pancreatic beta …

The autoimmune destruction of the pancreatic islet β cells is due to a targeted lymphocyte
attack. Different T cell subsets communicate with each other and with the insulin-producing β …