Neuropathic pain: mechanism-based therapeutics

K Bannister, J Sachau, R Baron… - Annual Review of …, 2020 - annualreviews.org
Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

Mechanisms of disease: neuropathic pain—a clinical perspective

R Baron - Nature clinical practice Neurology, 2006 - nature.com
Neuropathic pain syndromes—pain after a lesion or disease of the peripheral or central
nervous system—are clinically characterized by spontaneous and evoked types of pain …

Neuropathic pain

L Colloca, T Ludman, D Bouhassira, R Baron… - Nature reviews Disease …, 2017 - nature.com
Neuropathic pain is caused by a lesion or disease of the somatosensory system, including
peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7–10% of the …

Neuropathic pain. The long path from mechanisms to mechanism-based treatment

R Baron - Der Anaesthesist, 2000 - europepmc.org
Clinical characteristics of neuropathic pain, ie pain after nervous system lesions, are burning
spontaneous pain, shooting pain attacks and evoked pains. Partly interacting …

Neuropathic pain: clinical characteristics and diagnostic workup

P Hansson - European Journal of Pain, 2002 - Elsevier
Neuropathic pain is part of the neurological disease spectrum and may be an expression of
severe medical pathology. Painful neuropathies have multiple disguises and may to a …

Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy

CJ Woolf - Life sciences, 2004 - Elsevier
Peripheral neuropathic pain, that clinical pain syndrome associated with lesions to the
peripheral nervous system, is characterized by positive and negative symptoms. Positive …

Therapeutic targets for the management of peripheral nerve injury-induced neuropathic pain

A Singh Jaggi, N Singh - … Formerly Current Drug Targets-CNS & …, 2011 - ingentaconnect.com
Neuropathic pain is a debilitating form of treatment resistant chronic pain and responds
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …

Towards physiologically based treatment of patients with neuropathic pain

MB Max - Pain, 1990 - journals.lww.com
In this issue, two articles by Sugimoto et al.[15] and Sindrup et al.[14] illustrate promising
approaches to developing more specific treatments for the neural abnormalities underlying …

Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons

M Thouaye, I Yalcin - Pharmacology & Therapeutics, 2023 - Elsevier
Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …

Central neuropathic pain

J Rosner, DC de Andrade, KD Davis… - Nature Reviews …, 2023 - nature.com
Central neuropathic pain arises from a lesion or disease of the central somatosensory
nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related …