Developmental regulation of bone formation in the jaw skeleton is essential to species-
specific adaptation. The jaws are derived from neural crest mesenchyme (NCM), a …

The Runx (runt‐related) family of transcription factors are important regulators of cell fate
decisions in early embryonic development, and in differentiation of tissues including blood …

Neural crest mesenchyme (NCM) controls species-specific pattern in the craniofacial
skeleton but how this cell population accomplishes such a complex task remains unclear. To …

The vertebrate skeleton forms via two distinct modes of ossification, membranous and
endochondral. Osteoblasts are also heterogeneous in embryonic origin; bone formed by …

Precise developmental control of jaw length is critical for survival, but underlying molecular
mechanisms remain poorly understood. The jaw skeleton arises from neural crest …

Background The mineralized skeleton is a major evolutionary novelty that has contributed to
the impressive morphological diversifications of the vertebrates. Essential to bone biology is …

Runt-related transcription factor 2 (RUNX2) is critical for the development of the vertebrate
bony skeleton. Unlike other RUNX family members, RUNX2 possesses a variable poly …

The vertebrate transcription factor protein Runx2 is regarded as a “master regulator” of bone
formation due to the dramatic loss of the osseous skeleton in the mouse homozygous …

The transcription factors RUNX2 and OSX have been shown to act sequentially to direct
mammalian osteoblast differentiation. RUNX2 is required during the early stages of …

Runx2 is a developmentally regulated gene in vertebrates and is essential for bone
formation and skeletal homeostasis. The induction of runx2-P1 isoform transcripts is a …