Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms

AJ Kunz Coyne, K Stamper, C Bleick… - Microbiology …, 2024 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) causes biofilm-related medical device
infections. Phage-antibiotic combinations offer potential therapy due to proven in vitro …

Eradication of Biofilm-Mediated Methicillin-Resistant Staphylococcus aureus Infections In Vitro: Bacteriophage-Antibiotic Combination

R Kebriaei, KL Lev, RM Shah, KC Stamper… - Microbiology …, 2022 - Am Soc Microbiol
Bacterial biofilms are difficult to eradicate and can complicate many infections by forming on
tissues and medical devices. Phage+ antibiotic combinations (PAC) may be more active on …

Optimization of phage-antibiotic combinations against Staphylococcus aureus biofilms

R Kebriaei, SM Lehman, RM Shah… - Microbiology …, 2023 - Am Soc Microbiol
Phage therapy has gained attention due to the spread of antibiotic-resistant bacteria and
narrow pipeline of novel antibiotics. Phage cocktails are hypothesized to slow the overall …

Does Treatment Order Matter? Investigating the Ability of Bacteriophage to Augment Antibiotic Activity against Staphylococcus aureus Biofilms

D Kumaran, M Taha, QL Yi, S Ramirez-Arcos… - Frontiers in …, 2018 - frontiersin.org
The inability to effectively treat biofilm-related infections is a major clinical challenge. This
has been attributed to the heightened antibiotic tolerance conferred to bacterial cells …

Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility

AJK Coyne, K Stamper, R Kebriaei, DJ Holger… - Antibiotics, 2022 - mdpi.com
Multidrug-resistant (MDR) Enterococcus faecium is a challenging nosocomial pathogen
known to colonize medical device surfaces and form biofilms. Bacterio (phages) may …

APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting Staphylococcus aureus and MRSA Biofilms

S Liu, K Hon, GS Bouras, AJ Psaltis… - International Journal of …, 2022 - mdpi.com
The high infection and mortality rate of methicillin-resistant Staphylococcus aureus (MRSA)
necessitates the urgent development of new treatment strategies. Bacteriophages (phages) …

Adjunct phage treatment enhances the effectiveness of low antibiotic concentration against Staphylococcus aureus biofilms in vitro

J Dickey, V Perrot - PloS one, 2019 - journals.plos.org
Phage therapy is drawing more interest as antibiotic resistance becomes an ever more
serious threat to public health. Bacterial biofilms represent a major obstacle in the fight …

Targeted enhancement of bacteriophage activity against antibioticresistant Staphylococcus aureus biofilms through an evolutionary assay

L Ponce Benavente, J Wagemans, D Hinkel… - Frontiers in …, 2024 - frontiersin.org
Staphylococcus aureus´ biofilm-forming ability and rapid resistance development pose a
significant challenge to successful treatment, particularly in postoperative complications …

Phage-antibiotic combinations in various treatment modalities to manage MRSA infections

A Loganathan, B Bozdogan, P Manohar… - Frontiers in …, 2024 - frontiersin.org
Introduction: The emergence of antibiotic resistance is a significant challenge in the
treatment of bacterial infections, particularly in patients in the intensive care unit (ICU) …

Synergy of Antibiotics and Antibiofilm Agents against Methicillin-Resistant Staphylococcus aureus Biofilms

C Deusenbery, O Carneiro, C Oberkfell… - ACS Infectious …, 2023 - ACS Publications
Methicillin-resistant Staphylococcus aureus (MRSA) infections are some of the most
common antibiotic-resistant infections, often exacerbated by the formation of biofilms. Here …