Overexpression of members of the BCL-2 family of pro-survival proteins is commonly
associated with unfavourable pathogenesis in cancer. The convergence of cytotoxic stress …

Over the last decade the molecular mechanisms controlling programmed cell death
(apoptosis) have become clearer. It appears that many physiological and damage signals …

Highlights•Antiapoptotic proteins of the Bcl-2 family are targets for anticancer drugs.•BH3
mimetics inhibit antiapoptotic proteins and exert in vitro antitumor activity.•Some BH3 …

Bcl-2-family proteins are critical regulators of cell life and death, with homologs found in
most animal species. In humans, six antiapoptotic members of the Bcl-2 family have been …

Escape from apoptosis is a key attribute of tumour cells and facilitates chemo-resistance.
The 'BCL-2-regulated'or 'intrinsic'apoptotic pathway integrates stress and survival signalling …

Tumor cell survival is highly dependent on the expression of certain pro-survival Bcl-2 family
proteins. An attractive therapeutic approach is to inhibit these proteins using agents that …

The'hallmarks of cancer'are generally accepted as a set of genetic and epigenetic
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …

Mutations that impair apoptosis contribute to cancer development and reduce the
effectiveness of conventional anti-cancer therapies. These insights and understanding of …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

Impaired apoptosis is both critical in cancer development and a major barrier to effective
treatment. In response to diverse intracellular damage signals, including those evoked by …