Purpose Tau deposition is a key pathological feature of Alzheimer's disease (AD) and other
neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined …

A next generation of tau PET tracers for the imaging of Alzheimer's disease and other
dementias has recently been developed. Whilst the new compounds have now entered …

18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic
feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18F …

Abnormal aggregation of tau in the brain is a major contributing factor in various
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of …

In several neurodegenerative diseases that are collectively called tauopathies, progressive
accumulation of tau in the brain is closely associated with neurodegeneration and cognitive …

In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high
affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥ 500×) in vitro …

Purpose To provide an overview on positron emission tomography (PET) imaging of tau
pathology in Alzheimer's disease (AD) and other neurodegenerative disorders. Results …

Aggregated tau protein is a major neuropathological substrate central to the
pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD) …

Purpose The aim of this study was to explore the cerebral distribution of the tau-specific PET
tracer [18 F] THK5317 (also known as (S)-[18 F] THK5117) retention in different stages of …

Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in
Alzheimer's disease and are considered to be targets for therapeutic intervention as well as …