Autophagy is a degradative process in which cellular organelles and proteins are recycled
to restore homeostasis and cellular metabolism. Autophagy can be either a prosurvival or a …

Lactaptin, the proteolytic fragment of human milk kappa-casein, induces the death of various
cultured cancer cells. The mechanisms leading to cell death after lactaptin treatment have …

Lactaptin, a human milk-derived protein, induces apoptosis in cultured tumor cells. We
designed a recombinant analog of lactaptin (RL2) and tested its antitumor activity. The …

Background: The Akt/mammalian target of rapamycin (mTOR) signalling pathway serves as
a critical regulator of cellular growth, proliferation and survival. Akt aberrant activation has …

Background Targeting autophagy is emerging as a promising strategy in cancer
therapeutics in recent years. Autophagy can be modulated to drive cancer cell deaths that …

Present study aimed to elucidate the anticancer effect and the possible molecular
mechanism underlying the action of Latcripin 1 (LP1), from the mushroom Lentinula edodes …

Autophagy is a catabolic cellular process involving self-digestion and turnover of
macromolecules and entire organelles. Autophagy is primarily a protective process in …

Cancer cells activate autophagy in response to anticancer therapies. Autophagy induction is
a promising therapeutic approach to treat cancer. In a previous study, YL4073 inhibited the …

Background: Autophagy is a lysosome-mediated catabolic process that maintains cell
homeostasis and survival. It occurs not only in normal cells such as cardiac muscle cells …

Leukemia is caused by the malignant clonal expansion of hematopoietic stem cells, and in
adults, the most common type of leukemia is acute myeloid leukemia (AML). Autophagy …