Protection of mice against experimental cryptococcosis by synthesized peptides delivered in glucan particles
CA Specht, EJ Homan, CK Lee, Z Mou, CL Gomez… - MBio, 2022 - Am Soc Microbiol
The high global burden of cryptococcosis has made development of a protective vaccine a
public health priority. We previously demonstrated that a vaccine composed of recombinant …
public health priority. We previously demonstrated that a vaccine composed of recombinant …
[PDF][PDF] Vaccination with recombinant Cryptococcus proteins in glucan particles protects mice against cryptococcosis in a manner dependent upon mouse strain and …
CA Specht, CK Lee, H Huang, MM Hester, J Liu… - 2017 - core.ac.uk
Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and …
CA Specht, CK Lee, H Huang, MM Hester, J Liu… - MBio, 2017 - Am Soc Microbiol
Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
[HTML][HTML] Immunological correlates of protection following vaccination with glucan particles containing Cryptococcus neoformans chitin deacetylases
R Wang, LVN Oliveira, D Lourenco, CL Gomez, CK Lee… - npj Vaccines, 2023 - nature.com
Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin
deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here …
deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here …
Protection of mice against experimental cryptococcosis using glucan particle-based vaccines containing novel recombinant antigens
MM Hester, CK Lee, A Abraham, P Khoshkenar… - Vaccine, 2020 - Elsevier
Meningitis due to Cryptococcus neoformans is responsible for upwards of 180,000 deaths
worldwide annually, mostly in immunocompromised individuals. Currently there are no …
worldwide annually, mostly in immunocompromised individuals. Currently there are no …
[HTML][HTML] Cross-reactivity between vaccine antigens from the chitin deacetylase protein family improves survival in a mouse model of cryptococcosis
MM Hester, LVN Oliveira, R Wang, Z Mou… - Frontiers in …, 2022 - frontiersin.org
Meningitis due to the fungal pathogen Cryptococcus neoformans is estimated to cause
nearly 200,000 deaths annually, mostly in resource-limited regions. We previously identified …
nearly 200,000 deaths annually, mostly in resource-limited regions. We previously identified …
Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts
CA Specht, CK Lee, H Huang, DJ Tipper, ZT Shen… - MBio, 2015 - Am Soc Microbiol
ABSTRACT A vaccine capable of protecting at-risk persons against infections due to
Cryptococcus neoformans and Cryptococcus gattii could reduce the substantial global …
Cryptococcus neoformans and Cryptococcus gattii could reduce the substantial global …
[HTML][HTML] Immune evasion by Cryptococcus gattii in vaccinated mice coinfected with C. neoformans
MM Hester, D Carlson, JK Lodge, SM Levitz… - Frontiers in …, 2024 - frontiersin.org
Cryptococcus neoformans and C. gattii, the etiologic agents of cryptococcosis, cause over
100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to …
100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to …
[HTML][HTML] Vaccine and immunotherapeutic approaches for the prevention of cryptococcosis: lessons learned from animal models
CR Hole, FL Wormley Jr - Frontiers in microbiology, 2012 - frontiersin.org
Cryptococcus neoformans and C. gattii, the predominant etiological agents of
cryptococcosis, can cause life-threatening infections of the central nervous system in …
cryptococcosis, can cause life-threatening infections of the central nervous system in …
Promising whole‐cell vaccines against cryptococcosis
K Ueno, S Tsuge, K Shimizu… - Microbiology and …, 2023 - Wiley Online Library
Cryptococcosis is a mycosis caused by Cryptococcus neoformans and C. gattii species
complexes. Although this infection is potentially lethal, no prophylactic vaccine is yet …
complexes. Although this infection is potentially lethal, no prophylactic vaccine is yet …
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