Optimized sample preparation for fecal volatile organic compound analysis by gas chromatography–mass spectrometry

S el Manouni el Hassani, RJ Soers, DJC Berkhout… - Metabolomics, 2020 - Springer
Introduction Headspace gas chromatography–mass spectrometry (HS-GC–MS) is widely
considered the gold standard of quantitative fecal VOC analysis. However, guidelines …

Application of fecal volatile organic compound analysis in clinical practice: Current state and future perspectives

S El Manouni el Hassani, DJC Berkhout, S Bosch… - Chemosensors, 2018 - mdpi.com
Increasing interest is noticed in the potential of volatile organic compound (VOC) analysis as
non-invasive diagnostic biomarker in clinical medical practice. The spectrum of VOCs …

Effects of sampling conditions and environmental factors on fecal volatile organic compound analysis by an electronic nose device

DJC Berkhout, MA Benninga, RM Van Stein… - Sensors, 2016 - mdpi.com
Prior to implementation of volatile organic compound (VOC) analysis in clinical practice,
substantial challenges, including methodological, biological and analytical difficulties are …

[PDF][PDF] Optimisation of sample preparation for direct SPME-GC-MS analysis of murine and human faecal volatile organic compounds for metabolomic studies

S Reade, A Mayor, R Aggio, T Khalid… - J Anal Bioanal …, 2014 - researchgate.net
The analysis of volatile organic compounds (VOCs) emitted from biological fluids such as
blood, urine, breath and faeces, has been receiving more attention from researchers and …

Development of a screening method to determine the pattern of fermentation metabolites in faecal samples using on-line purge-and-trap gas chromatographic–mass …

V De Preter, G Van Staeyen, D Esser… - … of chromatography A, 2009 - Elsevier
An on-line screening method to analyse volatile organic compounds (VOCs) in faecal
samples was developed. VOCs were isolated from a standard solution or faecal samples …

The influence of lifestyle factors on fecal volatile organic compound composition as measured by an electronic nose

S Bosch, JPM Lemmen, R Menezes… - Journal of breath …, 2019 - iopscience.iop.org
Introduction: Fecal volatile organic compounds (VOCs) are gaseous metabolic products
which are increasingly considered potential non-invasive biomarkers for the detection of …

Solid-phase microextraction and the human fecal VOC metabolome

E Dixon, C Clubb, S Pittman, L Ammann, Z Rasheed… - PloS one, 2011 - journals.plos.org
The diagnostic potential and health implications of volatile organic compounds (VOCs)
present in human feces has begun to receive considerable attention. Headspace solid …

The optimization and comparison of two high-throughput faecal headspace sampling platforms: the microchamber/thermal extractor and hi-capacity sorptive extraction …

R van Vorstenbosch, A Mommers… - Journal of Breath …, 2024 - iopscience.iop.org
Disease detection and monitoring using Volatile Organic Compounds (VOCs) is becoming
increasingly popular. For a variety of (gastrointestinal) diseases the microbiome should be …

Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease

CE Garner, S Smith, B de Lacy Costello… - The FASEB …, 2007 - Wiley Online Library
Little is known about the volatile organic compounds (VOCs) in feces and their potential
health consequences. Patients and healthcare professionals have observed that feces often …

The approach to sample acquisition and its impact on the derived human fecal microbiome and VOC metabolome

RD Couch, K Navarro, M Sikaroodi, P Gillevet… - PloS one, 2013 - journals.plos.org
Recent studies have illustrated the importance of the microbiota in maintaining a healthy
state, as well as promoting disease states. The intestinal microbiota exerts its effects …