Incorporation of nucleoside analogues by the mitochondrial DNA polymerase has been
implicated as the primary cause underlying many of the toxic side effects of these drugs in …

Several of the nucleoside analogs used in the treatment of AIDS exhibit a delayed clinical
toxicity limiting their usefulness. The toxicity of nucleoside analogs may be related to their …

To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of
nucleoside analogs used to treat AIDS, we examined the kinetics of incorporation catalyzed …

Inhibition constants were determined for 16 nucleoside analog triphosphates against human
DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were …

Mitochondrial toxicity can result from antiviral nucleotide analog therapy used to control
human immunodeficiency virus type 1 infection. We evaluated the ability of such analogs to …

Although antiviral nucleoside analog therapy successfully delays progression of HIV
infection to AIDS, these drugs cause unwelcome side-effects by inducing mitochondrial …

OBJECTIVE: This paper reviews the function of the mitochondria and the mechanisms by
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …

Saccharomyces cerevisiae mtDNA polymerase, isolated as a single 135-kDa recombinant
polypeptide, showed high processivity and a capacity to use poly (dA)• oligo (dT), poly (rA)• …

Nucleoside reverse transcriptase inhibitors suppress HIV replication by blocking reverse
transcriptase, an RNA-dependent DNA polymerase. These drugs can also affect cellular and …

Nucleoside analogues represent the cornerstones of antiretroviral regimens. A range of drug-
or tissue-specific toxicities, such as peripheral neuropathy, myopathy, pancreatitis and lactic …