Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase
H Lee, J Hanes, KA Johnson - Biochemistry, 2003 - ACS Publications
Incorporation of nucleoside analogues by the mitochondrial DNA polymerase has been
implicated as the primary cause underlying many of the toxic side effects of these drugs in …
implicated as the primary cause underlying many of the toxic side effects of these drugs in …
Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs
JY Feng, AA Johnson, KA Johnson… - Journal of Biological …, 2001 - ASBMB
Several of the nucleoside analogs used in the treatment of AIDS exhibit a delayed clinical
toxicity limiting their usefulness. The toxicity of nucleoside analogs may be related to their …
toxicity limiting their usefulness. The toxicity of nucleoside analogs may be related to their …
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase
To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of
nucleoside analogs used to treat AIDS, we examined the kinetics of incorporation catalyzed …
nucleoside analogs used to treat AIDS, we examined the kinetics of incorporation catalyzed …
Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
JL Martin, CE Brown, N Matthews-Davis… - Antimicrobial agents …, 1994 - Am Soc Microbiol
Inhibition constants were determined for 16 nucleoside analog triphosphates against human
DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were …
DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were …
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase γ
SE Lim, WC Copeland - Journal of Biological Chemistry, 2001 - ASBMB
Mitochondrial toxicity can result from antiviral nucleotide analog therapy used to control
human immunodeficiency virus type 1 infection. We evaluated the ability of such analogs to …
human immunodeficiency virus type 1 infection. We evaluated the ability of such analogs to …
Structural determinants in human DNA polymerase γ account for mitochondrial toxicity from nucleoside analogs
SE Lim, MV Ponamarev, MJ Longley… - Journal of molecular …, 2003 - Elsevier
Although antiviral nucleoside analog therapy successfully delays progression of HIV
infection to AIDS, these drugs cause unwelcome side-effects by inducing mitochondrial …
infection to AIDS, these drugs cause unwelcome side-effects by inducing mitochondrial …
Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity
TN Kakuda - Clinical therapeutics, 2000 - Elsevier
OBJECTIVE: This paper reviews the function of the mitochondria and the mechanisms by
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase
S Eriksson, B Xu, DA Clayton - Journal of Biological Chemistry, 1995 - ASBMB
Saccharomyces cerevisiae mtDNA polymerase, isolated as a single 135-kDa recombinant
polypeptide, showed high processivity and a capacity to use poly (dA)• oligo (dT), poly (rA)• …
polypeptide, showed high processivity and a capacity to use poly (dA)• oligo (dT), poly (rA)• …
Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: a looming obstacle for long-term antiretroviral therapy?
K Brinkman, TN Kakuda - Current opinion in infectious diseases, 2000 - journals.lww.com
Nucleoside reverse transcriptase inhibitors suppress HIV replication by blocking reverse
transcriptase, an RNA-dependent DNA polymerase. These drugs can also affect cellular and …
transcriptase, an RNA-dependent DNA polymerase. These drugs can also affect cellular and …
Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism?
G Moyle - Drug safety, 2000 - Springer
Nucleoside analogues represent the cornerstones of antiretroviral regimens. A range of drug-
or tissue-specific toxicities, such as peripheral neuropathy, myopathy, pancreatitis and lactic …
or tissue-specific toxicities, such as peripheral neuropathy, myopathy, pancreatitis and lactic …
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