Role of autophagy in HIV-1 and drug abuse-mediated neuroinflammaging
Chronic low-grade inflammation remains an essential feature of HIV-1 infection under
combined antiretroviral therapy (cART) and contributes to the accelerated cognitive defects …
combined antiretroviral therapy (cART) and contributes to the accelerated cognitive defects …
Neuroinflammation & pre-mature aging in the context of chronic HIV infection and drug abuse: Role of dysregulated autophagy
ML Guo, S Buch - Brain research, 2019 - Elsevier
In the era of combined antiretroviral therapy (cART), HIV-1 infection has transformed from a
death sentence to a manageable, chronic disease. Although the life expectancy of HIV+ …
death sentence to a manageable, chronic disease. Although the life expectancy of HIV+ …
Role of inflammasomes in HIV-1 and drug abuse mediated neuroinflammaging
Despite the effectiveness of combined antiretroviral therapy (cART) in suppressing virus
replication, chronic inflammation remains one of the cardinal features intersecting HIV-1 …
replication, chronic inflammation remains one of the cardinal features intersecting HIV-1 …
Aberrant autophagy in macrophages and astrocytes after HIV Nef or antiretroviral treatment: contribution to the pathogenesis of HIV-associated neurocognitive …
L Cheney, T Calderon, AM Cuervo… - Open Forum Infectious …, 2017 - ncbi.nlm.nih.gov
Background Despite antiretroviral therapy (ART), HIV-associated neurocognitive disorders
(HAND) still affect 40–70% of HIV-infected people. The pathogenesis of HAND is multi …
(HAND) still affect 40–70% of HIV-infected people. The pathogenesis of HAND is multi …
N-Acetylcysteine reverses antiretroviral-mediated microglial activation by attenuating autophagy-lysosomal dysfunction
Successful suppression of viral replication by combined antiretroviral therapy (cART) in HIV-
1 infected individuals is paradoxically also accompanied by an increased prevalence of HIV …
1 infected individuals is paradoxically also accompanied by an increased prevalence of HIV …
HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders
Antiretroviral therapy has increased the life span of HIV+ individuals; however, HIV-
associated neurocognitive disorder (HAND) occurrence is increasing in aging HIV patients …
associated neurocognitive disorder (HAND) occurrence is increasing in aging HIV patients …
Endoplasmic reticulum stress and autophagy in HIV-1-associated neurocognitive disorders
X Chen, T Zhang, Y Zhang - Journal of NeuroVirology, 2020 - Springer
Although antiretroviral therapy (ART) affects virologic suppression and prolongs life
expectancies among HIV-positive patients; HIV-1-associated neurocognitive disorders …
expectancies among HIV-positive patients; HIV-1-associated neurocognitive disorders …
HIV-1 Nef blocks autophagy in human astrocytes
HIV is a pandemic virus and the causative agent of AIDS. The development of combination
antiretroviral therapy (cART) significantly improved the length and quality of life of HIV …
antiretroviral therapy (cART) significantly improved the length and quality of life of HIV …
HIV increases the inhibitory impact of morphine and antiretrovirals on autophagy in primary human macrophages: contributions to neuropathogenesis
JM Barbaro, AM Cuervo, JW Berman - Cells, 2021 - mdpi.com
HIV enters the CNS early after peripheral infection, establishing reservoirs in perivascular
macrophages that contribute to development of HIV-associated neurocognitive disorders …
macrophages that contribute to development of HIV-associated neurocognitive disorders …
HIV-1 differentially modulates autophagy in neurons and astrocytes
R Mehla, A Chauhan - Journal of neuroimmunology, 2015 - Elsevier
Autophagy, a lysosomal degradative pathway that maintains cellular homeostasis, has
emerged as an innate immune defense against pathogens. The role of autophagy in the …
emerged as an innate immune defense against pathogens. The role of autophagy in the …