Regulation of glucose metabolism is a crucial aspect of cell physiology in normal and
disease conditions. Many regulatory events are involved in determining the metabolic fate of …

Publisher Summary This chapter explains the enzyme system that catalyzes the
biosynthesis and biodegradation of Fru-2, 6-P 2. The characterization of this system and of …

6-Phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFK-2/FBPase) catalyzes the
synthesis and degradation of fructose 2, 6-bisphosphate (F2, 6BP), which is a powerful …

Fru-2, 6-P2 (fructose 2, 6-bisphosphate) is a signal molecule that controls glycolysis. Since
its discovery more than 20 years ago, inroads have been made towards the understanding …

Abstract Fructose-2, 6-bisphosphate is responsible for mediating glucagon-stimulated
gluconeogenesis in the liver. This discovery has led to the realization that this compound …

Fructose-2, 6-bisphosphate (F26P2) was identified as a regulator of glucose metabolism
over 25 years ago. A truly bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2, 6 …

When oxygen becomes limiting, cells shift primarily to a glycolytic mode for generation of
energy. A key regulator of glycolytic flux is fructose-2, 6-bisphosphate (F-2, 6-BP), a potent …

Tumor cells increase glucose metabolism through glycolysis and pentose phosphate
pathways to meet the bioenergetic and biosynthetic demands of rapid cell proliferation. The …

The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFK-
2/FBPase-2) was recently identified as a new intracellular binding partner for glucokinase …

Fructose 2, 6-bisphosphate (Fru-2, 6-P2) was discovered during investigations into the
mechanism whereby glucagon, via its second messenger cAMP, stimu lates …