Role of the p16 tumor suppressor gene in cancer.
WH Liggett Jr, D Sidransky - Journal of clinical oncology, 1998 - ascopubs.org
Since its discovery as a CDKI (cyclin-dependent kinase inhibitor) in 1993, the tumor
suppressor p16 (INK4A/MTS-1/CDKN2A) has gained widespread importance in cancer. The …
suppressor p16 (INK4A/MTS-1/CDKN2A) has gained widespread importance in cancer. The …
p16 (MTS-1/CDKN2/INK4a) in cancer progression
JW Rocco, D Sidransky - Experimental cell research, 2001 - Elsevier
Since its discovery as an inhibitor of cyclin-dependent kinases 4 and 6, the tumor
suppressor p16 has continued to gain widespread importance in cancer. The high frequency …
suppressor p16 has continued to gain widespread importance in cancer. The high frequency …
CDKN2A (p16INK4A) somatic and germline mutations
B Smith‐Sørensen, E Hovig - Human mutation, 1996 - Wiley Online Library
The cell cycle is composed of a series of steps that can be negatively or positively regulated
by various factors. A group of low‐molecular‐weight proteins have recently been identified …
by various factors. A group of low‐molecular‐weight proteins have recently been identified …
Cancer‐associated mis‐sense and deletion mutations impair p16INK4 CDK inhibitory activity
R Lilischkis, B Sarcevic, C Kennedy… - … journal of cancer, 1996 - Wiley Online Library
The p16INK4 gene is a candidate tumour‐suppressor gene which maps to the genomic
locus 9p21, and mutations of this gene are associated with melanoma and other cancers …
locus 9p21, and mutations of this gene are associated with melanoma and other cancers …
p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma
JO Funk, PI Schiller, MT Barrett… - Journal of cutaneous …, 1998 - Wiley Online Library
The product of the p16/INK4a/CDKN2/MTS1 tumor‐suppressor gene acts as a negative cell
cycle regulator by inhibiting G1 cyclin‐dependent kinases that phosphorylate the …
cycle regulator by inhibiting G1 cyclin‐dependent kinases that phosphorylate the …
Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage
L Talve, I Sauroja, Y Collan… - … journal of cancer, 1997 - Wiley Online Library
The G1/S checkpoint of the cell cycle is regulated by p16, p53 and RB tumor suppressor
genes. Loss of expression of the p16INK4 tumor suppressor protein, the product of the …
genes. Loss of expression of the p16INK4 tumor suppressor protein, the product of the …
Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma
O Straume, L Sviland, LA Akslen - Clinical Cancer Research, 2000 - AACR
Abstract The CDKN2A (p16 INK4a) cell cycle-inhibitory gene has been associated with
development of familial melanoma. Additionally, recent studies indicate that p16 alterations …
development of familial melanoma. Additionally, recent studies indicate that p16 alterations …
High Frequency of p16 (CDKN2/MTS-1/INK4A) Inactivation in Head and Neck Squamous Cell Carcinoma
AL Reed, J Califano, P Cairns, WH Westra, RM Jones… - Cancer research, 1996 - AACR
The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) can be inactivated by multiple
genetic mechanisms. We analyzed 29 invasive primary head and neck squamous cell …
genetic mechanisms. We analyzed 29 invasive primary head and neck squamous cell …
Loss of Expression of the p16/Cyclin-dependent Kinase Inhibitor 2 Tumor Suppressor Gene in Melanocytic Lesions Correlates with Invasive Stage of Tumor …
JA Reed, F Loganzo Jr, CR Shea, GJ Walker, JF Flores… - Cancer research, 1995 - AACR
Sporadic and familial malignant melanoma susceptibility has been linked to defects in the
chromosomal region 9p21. Recently, a putative 9p21 tumor suppressor gene, the cyclin …
chromosomal region 9p21. Recently, a putative 9p21 tumor suppressor gene, the cyclin …
Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma.
L Liu, NJ Lassam, JM Slingerland, D Bailey, D Cole… - Oncogene, 1995 - europepmc.org
The gene encoding the cell cycle inhibitor p16INK4A (also known as p16, MTS1, CDKN2
and INK4) has been mapped to human chromosome band 9p21, a region that also contains …
and INK4) has been mapped to human chromosome band 9p21, a region that also contains …