Background Neural tube defects (NTDs) are among the most common and severe
congenital defects in humans. Their genetic etiology is complex and remains poorly …

ABSTRACT MED13L is a component subunit of the M ediator complex, an important
regulator of transcription that is highly conserved across eukaryotes. Here, we report …

Abstract Background Neural tube defects (NTDs) are failure of neural tube closure, which
includes multiple central nervous system phenotypes. More than 300 mouse mutant strains …

Background Neural tube defects (NTD) are among the most common defects affecting 1:
1000 births. They are caused by a failure of neural tube closure during development. Their …

Neural tube defects (NTDs) are a heterogeneous set of malformations attributed to
disruption in normal neural tube closure during early embryogenesis. An in‐depth …

BACKGROUND: A precise temporal and spatial regulation of gene expression is necessary
to achieve neural tube closure. Med12, a subunit of the mediator complex, can bind …

Every year nearly 6 percent of children worldwide are born with a serious congenital
malformation, resulting in death or lifelong disability. In the United States, birth defects …

Purpose MED12 is a subunit of the Mediator multiprotein complex with a central role in RNA
polymerase II transcription and regulation of cell growth, development, and differentiation …

Neurulation, the early embryonic process of forming the presumptive brain and spinal cord,
is highly complex and involves hundreds of genes in multiple genetic pathways. Mice have …

MED12 is a member of the large Mediator complex that controls cell growth, development,
and differentiation. Mutations in MED12 disrupt neuronal gene expression and lead to at …