The regeneration of bone in segmental defects has historically been a challenge in the
orthopedic field. In particular, a lack of vascular supply often leads to nonunion and …

A variety of engineered materials have gained acceptance in orthopedic practice as
substitutes for autologous bone grafts, although the regenerative efficacy of these …

Over the last decades, the medical world has advanced dramatically in the understanding of
fracture repair. The three components needed for fracture healing are osteoconduction …

Bone loss due to trauma or disease is an increasingly serious health problem. Current
clinical treatments for critical-sized defects are problematic and often yield poor healing due …

Bone generally displays a high intrinsic capacity to regenerate. Nonetheless, large osseous
defects sometimes fail to heal. The treatment of such large segmental defects still represents …

Repair of non-healing bone defects through tissue engineering strategies remains a
challenging feat in the clinic due to the aversive microenvironment surrounding the injured …

Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

The successful regeneration of bone tissue to replace areas of bone loss in large defects or
at load‐bearing sites remains a significant clinical challenge. Over the past few decades …

Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and
remain a clinical challenge. Healing such defects requires the formation of large amounts of …

The current strategies for healing bone defects are numerous and varied. At the core of each
bone healing therapy is a biomimetic mechanism, which works to enhance bone growth …