Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an
endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly …

Background Tumor necrosis factor-α (TNF-α) is a potent proinflammatory cytokine involved
in a variety of disease pathologies, including ischemia/reperfusion (I/R) injuries in …

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …

Background & Aims: The tumor necrosis factor (TNF)-α/TNF receptor system is critical for
liver development because hepatocytes undergo apoptosis if the antiapoptotic cascades …

Tumor necrosis factor‐α (TNF) is an inflammatory cytokine that induces context‐dependent
proliferation, survival, and apoptosis responses in hepatocytes. TNF stimulates and …

The liver is a unique organ with respect to its anatomical location, allowing continuous blood
flow from the gastrointestinal tract through the sinusoids, and its cellular composition …

The proinflammatory cytokine TNF has a pivotal role in liver pathophysiology because it
holds the capacity to induce both hepatocyte cell death and hepatocyte proliferation. This …

TNF-α is a pleotropic proinflammatory cytokine that has been implicated as a contributing
factor in a number of disease processes, primarily through its ability to induce the expression …

Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

One of the earliest TNF-dependent events to occur during liver regeneration is the activation
of the transcription factor NF-κB through TNF receptor type 1. NF-κB activation in the liver …