The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …

Summary Stem Cell Factor (SCF) initiates its multiple cellular responses by binding to the
ectodomain of KIT, resulting in tyrosine kinase activation. We describe the crystal structure of …

Stem cell factor (SCF) binds to and activates the KIT receptor, a class III receptor tyrosine
kinase (RTK), to stimulate diverse processes including melanogenesis, gametogenesis and …

ABSTRACT Kit‐ligand (Kitl), also known as stem cell factor, is a membrane‐anchored,
noncovalently bound dimer signaling via the c‐kit receptor tyrosine kinase, required for …

In this issue, Schlessinger and his colleagues (Yuzawa et al., 2007) describe crystal
structures of the complete extracellular region of the Kit receptor tyrosine kinase, both alone …

The receptor tyrosine kinase KIT plays an important role in development of germ cells,
hematopoietic cells, and interstitial pacemaker cells. Oncogenic KIT mutations play an …

Using electron microscopy and fitting of crystal structures, we present the 3D reconstruction
of ligand-induced dimers of intact receptor tyrosine kinase, KIT. We observe that KIT …

Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis,
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …

The Kit receptor tyrosine kinase is critical for normal hematopoiesis. Mutation of the aspartic
acid residue encoded by codon 816 of human c-kit or codon 814 of the murine gene results …

The c-Kit proto-oncogene is a receptor protein-tyrosine kinase associated with several
highly malignant human cancers. Upon binding its ligand, stem cell factor (SCF), c-Kit forms …