After Heberden's description of patients with “angina pectoris” in 1768, for over 125 years
most physicians believed that the disease was immediately fatal. The growing realization …

For the greater part of the 20th century, the pathophysiology of acute myocardial infarction
regarding whether thrombosis was either present or primary was debated until 1973 when …

In recent years the widely held concept that coronary thrombi cause myocardial infarcts has
been seriously questioned. On the basis of pathologic studies, several reports have …

It is a sobering experience to read the astute observations describing the link between
thrombosis and the clinical manifestations of ischemic heart disease made by some of the …

The development of coronary thrombi is related to the pathogenesis of the underlying
lesions of the arterial wall. Intimal hemorrhage and rupture of atherosclerotic plaques are …

IN RECENT years the role of coronary thrombosis as a precipitating cause of acute
myocardial infarction (AMI) has been questioned." Which comes first, coronary thrombosis or …

JAMES B. HERRICK was an outstanding clinicianscientist who joined with other clinical
cardiologists in founding the American Heart Association in 1915. During his 92 years of life …

Abstract On December 7, 1912 a great Chicago physician, Dr. James B. Herrick, published
his now famous paper in the JAMA in which he related for the first time the “Clinical Features …

Introduction. Coronary thrombosis with infarction of the heart as a clinical entity is a condition
which is generally classed among the rarities of medicine. Indeed, it is considered so rare …

The coronary arteries are diffusely involved by atherosclerotic plaques in fatal acute
myocardial infarction (AMI). The degree of luminal narrowing may vary but plaques are …