The science of making drug-addicted animals

SH Ahmed - Neuroscience, 2012 - Elsevier
Research involving animal models of drug addiction can be viewed as a sort of reverse
psychiatry. Contrary to clinicians who seek to treat addicted people to become and remain …

Animal models of psychoactive drug use and addiction–present problems and future needs for translational approaches

CP Müller - Behavioural Brain Research, 2018 - Elsevier
Drug addiction is a psychiatric disorder based on a dysfunction of the brain. It frequently
develops from a controlled drug consumption and drug instrumentalization (DI). Thereby, DI …

Are animal models of addiction useful?

M Field, I Kersbergen - Addiction, 2020 - Wiley Online Library
Background Pre‐clinical research involving non‐human animals has made important
contributions to our understanding of risk factors for addiction, neuroadaptations that follow …

Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction

SH Ahmed - Neuroscience & Biobehavioral Reviews, 2010 - Elsevier
In standard drug self-administration settings, animals have no choice than drug use. As a
result, serious doubt exists about the interpretation of drug use in experimental animals. Is it …

Animal studies of addictive behavior

LJMJ Vanderschuren… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
It is increasingly recognized that studying drug taking in laboratory animals does not equate
to studying genuine addiction, characterized by loss of control over drug use. This has …

Animal models of drug addiction

GF Koob, FE Bloom, DJ Kupfer - … FE, Kupfer DJ—1995.—345 p, 2012 - books.google.com
Drug addiction can be defined as a chronically relapsing disorder characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …

Critical assessment of how to study addiction and its treatment: human and non-human animal models

CP O'Brien, EL Gardner - Pharmacology & therapeutics, 2005 - Elsevier
Laboratory models, both animal and human, have made enormous contributions to our
understanding of addiction. For addictive disorders, animal models have the great …

Compulsive drug use and its neural substrates

HMB Lesscher, LJMJ Vanderschuren - Reviews in the …, 2012 - degruyter.com
Drug addiction is a chronic relapsing brain disease, characterized by compulsive drug use.
Despite the fact that drug addiction affects millions of people worldwide, treatments for this …

[HTML][HTML] Understanding addiction using animal models

BN Kuhn, PW Kalivas, AC Bobadilla - Frontiers in behavioral …, 2019 - frontiersin.org
Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …

How preclinical models evolved to resemble the diagnostic criteria of drug addiction

A Belin-Rauscent, M Fouyssac, A Bonci, D Belin - Biological psychiatry, 2016 - Elsevier
Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals
who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained …