Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation
of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Neurodegenerative diseases are a diverse class of diseases attributed to chronic
progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord …

Iron, through its participation in oxidation/reduction processes, is essential for the
physiological function of biological systems. In the brain, iron is involved in the development …

Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Iron is an essential transition metal for numerous biologic processes in mammals. Iron
metabolism is regulated via several coordination mechanisms including absorption …

Iron plays a role for the biogenesis of two important redox‐reactive prosthetic groups of
enzymes, iron sulphur clusters (ISC) and heme. A part of these biosynthetic pathways takes …