Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …

Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

Mitochondrial diseases can be related to mutations in either the nuclear or mitochondrial
genome. Childhood presentations are commonly associated with renal tubular dysfunction …

Kidneys have a high energy demand to facilitate the reabsorption of the glomerular filtrate.
For this reason, renal cells have a high density of mitochondria. Mitochondrial cytopathies …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …

Mitochondrial cytopathies include a heterogeneous group of diseases that are characterized
by impaired oxidative phosphorylation, leading to multi organ involvement and progressive …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Mitochondria are intracellular organelles with a variety of vital functions, including the
provision of energy in the form of adenosine 5′-triphosphate. Increasingly, we are …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …