IL-33 is a well-studied cytokine that resides normally within nuclei but can be released by
cell damage or stress to then signal via a single receptor widely expressed on immune cells …

IL-33 induces airway inflammation and hyper-responsiveness in respiratory diseases.
Although defined as a therapeutic target, there are limited studies that have …

© Journal of Thoracic Disease. All rights reserved. J Thorac Dis 2016; 8 (10): E1364-E1366
jtd. amegroups. com including group 2 innate lymphoid cells (ILC2), Th2 cells, eosinophils …

IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that
signals through the ST2 receptor and drives cytokine production in mast cells, basophils …

Abstract IL-33, an IL-1 family cytokine, is constitutively expressed in mucosal tissues and
other organs in healthy humans and animals, and expression levels increase in …

IL-33, a novel IL-1 family member, is crucially expressed and involved in pulmonary
diseases, but its regulation in viral diseases such as influenza A virus (IAV) remains unclear …

Tissue infiltration by circulating monocytes is a critical step in the initiation and augmentation
of type 2 inflammatory responses in the lungs. Our studies demonstrate that IL-33−/− mice …

Respiratory syncytial virus (RSV)-induced immunopathogenesis and disease severity in
neonatal mice and human infants have been related to elevated pulmonary IL-33. Thus …

Rationale: IL-33 is an IL-1 family member and the functional ligand of the T1/ST2 receptor,
and is thought to be predominantly released following injury and necrosis. Although initially …

Background Rhinovirus infection triggers acute asthma exacerbations. IL-33 is an instructive
cytokine of type 2 inflammation whose expression is associated with viral load during …