B cell activating factor (BAFF): structure, functions, autoimmunity and clinical implications in systemic lupus erythematosus (SLE)

T Möckel, F Basta, J Weinmann-Menke… - Autoimmunity reviews, 2021 - Elsevier
The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival
factor which supports autoreactive B cells and prevents their deletion. BAFF expression is …

BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus

FB Vincent, EF Morand… - Immunology and cell …, 2012 - Wiley Online Library
Recently, the B cell has emerged as a cornerstone of systemic lupus erythematosus (SLE)
pathogenesis. This has been highlighted by studies of the cytokine B‐cell‐activating factor of …

Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases

E Samy, S Wax, B Huard, H Hess… - International reviews of …, 2017 - Taylor & Francis
The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-
inducing ligand), are critical factors in the maintenance of the B cell pool and humoral …

BAFF and selection of autoreactive B cells

Z Liu, A Davidson - Trends in immunology, 2011 - cell.com
B cell activating factor (BAFF) is a crucial survival factor for transitional and mature B cells,
and is a promising therapeutic target for systemic lupus erythematosus (SLE). A BAFF …

The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity

FB Vincent, D Saulep-Easton, WA Figgett… - Cytokine & growth factor …, 2013 - Elsevier
The BAFF system plays a key role in the development of autoimmunity, especially in
systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly …

B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling

F Mackay, PA Silveira, R Brink - Current opinion in immunology, 2007 - Elsevier
B-cell activation factor from the tumor necrosis factor family (BAFF) is a key survival factor
during B-cell maturation—a delicate immune checkpoint for B cells. Excessive BAFF …

Cracking the BAFF code

F Mackay, P Schneider - Nature reviews immunology, 2009 - nature.com
The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL
(a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess …

Association of BAFF, APRIL serum levels, BAFF-R, TACI and BCMA expression on peripheral B-cell subsets with clinical manifestations in systemic lupus …

DC Salazar-Camarena, PC Ortiz-Lazareno, A Cruz… - Lupus, 2016 - journals.sagepub.com
Objective B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL)
signaling pathways regulate B-cell survival through interactions with their receptors BAFF-R …

BAFF: a local and systemic target in autoimmune diseases

I Moisini, A Davidson - Clinical & Experimental Immunology, 2009 - academic.oup.com
BAFF (B lymphocyte activating factor of the tumour necrosis factor family) is a vital
homeostatic cytokine for B cells that helps regulate both innate and adaptive immune …

Functional and clinical aspects of the B‐cell‐activating factor (BAFF): a narrative review

GA Lied, A Berstad - Scandinavian journal of immunology, 2011 - Wiley Online Library
B‐cell‐activating factor (BAFF) influences peripheral B‐cell survival, maturation and
immunoglobulin class‐switch recombination and has a range of potential clinical …