Objectives To investigate whether the conclusion of a recent systematic review and network
meta-analysis (Cipriani et al) that antidepressants are more efficacious than placebo for …

Background Major depressive disorder is estimated by the WHO to affect more than 300
million people globally, making depression the leading cause of disability worldwide …

With increasing numbers of treatment options available for patients with major depression
over the last decade and the growing body of evidence describing their efficacy and safety …

Background Although previous meta-analyses have examined effects of antidepressants,
psychotherapy, and alternative therapies for depression, the efficacy of these treatments …

Context Antidepressant medications represent the best established treatment for major
depressive disorder, but there is little evidence that they have a specific pharmacological …

Background Concern has been expressed about the relevance of secondary care studies to
primary care patients specifically about the effectiveness of antidepressant medication …

Objectives This study aims to summarise the evidence on more than 140 pharmacological
and non-pharmacological treatment options for major depressive disorder (MDD) and to …

Objectives: To examine the available scientific literature for answers to clinically relevant
questions regarding the effectiveness and tolerability of antidepressant drugs (ADs) for the …

Although the early antidepressant trials which included severely ill and hospitalized patients
showed substantial drug‐placebo differences, these robust differences have not held up in …

Background Depression in the physically unwell is common and an important cause of
morbidity. There are problems with diagnosing depression in the physically ill which may …