Objective To investigate the prevalence and spectrum of BRCA1 and BRCA2 mutations in
Chinese Hakka patients with breast and ovarian cancer. Methods A total of 1,664 breast or …

Objective To investigate the prevalence of BRCA1/2 gene variants and evaluate the clinical
and pathological characteristics associated with these variants in Chinese Hakka breast …

Objective To investigate the frequencies of BRCA1 and BRCA2 mutations in Chinese Hakka
patients with ovarian cancer. Methods The protein coding regions and exon intron boundary …

Germline mutations in BRCA1 and BRCA2 are the most penetrating genetic predispositions
for breast and ovarian cancer, and their presence is largely ethnic-specific. Comprehensive …

The identification and interpretation of germline BRCA1/2 variants become increasingly
important in breast and ovarian cancer (OC) treatment. However, there is no comprehensive …

Background Germline mutations in the BRCA1 and BRCA2 genes greatly increase a
woman's risk of developing breast and/or ovarian cancer. The prevalence and distribution of …

Objective Despite the discovery of breast and ovarian cancer predisposition genes BRCA1
and BRCA2 more than two decades ago, almost all the available data relate to women of …

Objective To investigate the BRCA status in Chinese patients with ovarian cancer (OC).
Though there were two large prevalence studies in Chinese OC patients, this was the first …

Background Ethnic variations in breast cancer epidemiology and genetics have
necessitated investigation of the spectra of BRCA1 and BRCA2 mutations in different …

Background The incidence of breast cancer (BC) and/or ovarian cancer (OC) is increasing in
Tunisia especially in young women and mostly those with family history. However, the …