[HTML][HTML] Critical Roles of the Circadian Transcription Factor BMAL1 in Reproductive Endocrinology and Fertility

Y Jiang, S Li, W Xu, J Ying, Y Qu, X Jiang… - Frontiers in …, 2022 - frontiersin.org
Brain and muscle aryl-hydrocarbon receptor nuclear translocator like protein1 (BMAL1), a
core component of circadian oscillation, is involved in many physiological activities …

Loss of Bmal1 decreases oocyte fertilization, early embryo development and implantation potential in female mice

J Xu, Y Li, Y Wang, Y Xu, C Zhou - Zygote, 2016 - cambridge.org
Biological clock genes expressed in reproductive tissues play important roles in maintaining
the normal functions of reproductive system. However, disruption of female circadian rhythm …

Impaired Steroidogenesis and Implantation Failure in Bmal1−/− Mice

CK Ratajczak, KL Boehle, LJ Muglia - Endocrinology, 2009 - academic.oup.com
Evidence in humans and rodents suggests that normal circadian rhythmicity is important for
supporting reproductive function. A molecular clock underlies circadian rhythmicity. Impaired …

[HTML][HTML] Core clock gene Bmal1 deprivation impairs steroidogenesis in mice luteinized follicle cells

Y Wang, M Chen, J Xu, X Liu, Y Duan, C Zhou… - …, 2020 - rep.bioscientifica.com
Luteinization is the event of corpus luteum formation, a way of follicle cells transformation
and a process of steroidogenesis alteration. As the core clock gene, Bmal1 was involved in …

[HTML][HTML] The circadian clock, nutritional signals and reproduction: a close relationship

M Ono, H Ando, T Daikoku, T Fujiwara… - International journal of …, 2023 - mdpi.com
The circadian rhythm, which is necessary for reproduction, is controlled by clock genes. In
the mouse uterus, the oscillation of the circadian clock gene has been observed. The …

The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice

JD Alvarez, A Hansen, T Ord, P Bebas… - Journal of biological …, 2008 - journals.sagepub.com
Although it is well established that the circadian clock regulates mammalian reproductive
physiology, the molecular mechanisms by which this regulation occurs are not clear. The …

Downregulation of core clock gene Bmal1 attenuates expression of progesterone and prostaglandin biosynthesis-related genes in rat luteinizing granulosa cells

H Chen, L Zhao, M Kumazawa… - … of Physiology-Cell …, 2013 - journals.physiology.org
Ovarian circadian oscillators have been implicated in the reproductive processes of
mammals. However, there are few reports regarding the detection of ovarian clock …

Bmal1 is required for normal reproductive behaviors in male mice

EL Schoeller, DD Clark, S Dey, NV Cao… - …, 2016 - academic.oup.com
Circadian rhythms synchronize physiological processes with the light-dark cycle and are
regulated by a hierarchical system initiated in the suprachiasmatic nucleus, a hypothalamic …

Generation of myometrium-specific Bmal1 knockout mice for parturition analysis

CK Ratajczak, M Asada, GC Allen… - Reproduction …, 2012 - CSIRO Publishing
Human and rodent studies indicate a role for circadian rhythmicity and associated clock
gene expression in supporting normal parturition. The importance of clock gene expression …

Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice

AL Mereness, ZC Murphy, AC Forrestel, S Butler… - …, 2016 - academic.oup.com
Rhythmic events in female reproductive physiology, including ovulation, are tightly
controlled by the circadian timing system. The molecular clock, a feedback loop oscillator of …