A more detailed understanding of the somatic genetic events that drive gastrointestinal
adenocarcinomas is necessary to improve diagnosis and therapy. Using data from high …

Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …

Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies,
even when guided by genomic biomarkers, have had limited efficacy. A potential reason for …

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to
examine shared and distinguishing molecular characteristics of gastrointestinal tract …

Gastric cancer and esophageal cancer are the second and sixth leading causes of cancer-
related death worldwide. Multiple genomic alterations underlying gastric cancer and …

Background Gastric cancer is the second highest cause of global cancer mortality. To
explore the complete repertoire of somatic alterations in gastric cancer, we combined …

Genomic copy number aberrations (CNAs) are believed to play a major role in the
development and progression of human cancers. Although many CNAs have been reported …

We applied whole-genome single-nucleotide polymorphism arrays to define a
comprehensive genetic profile of 23 esophageal adenocarcinoma (EAC) primary tumor …

Gastric cancer is a heterogeneous disease with diverse molecular and histological
subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with …

Background Gastroesophageal cancers are often grouped together even though cancers
that originate in the esophagus often exhibit different histological features, geographical …