Azido sugars have found frequent use as probes of biological systems in approaches
ranging from cell surface metabolic labeling to activity-based proteomic profiling of …

Metabolic chemical reporters (MCRs) provide easily accessible means to study glycans in
their native environments. However, because monosaccharide precursors are shared by …

Engineering of carbohydrate-active enzymes such as glycosynthases to enable
chemoenzymatic synthesis of bespoke oligosaccharides has been limited by the lack of …

The construction of large, phylogenetically diverse libraries of synthetic genes from a
sequence-based family allows rapid evaluation of the substrate specificity encoded within …

This JACS Select issue highlights current and emerging areas of research at the chemistry−
glycobiology interface and illustrates how chemical and physical approaches are being …

Carbohydrate metabolism is central to the growth and development of organisms.
Thousands of genes that are believed to code for proteins that build and remodel …

Metabolic chemical reports have fundamentally changed the way researchers study
glycosylation. However, when administered as per-O-acetylated sugars, reporter molecules …

Enzymatic cleavage of the glycosidic bond yields products in which the anomeric
configuration is either retained or inverted. Each mechanism reflects the dispositions of the …

Functional metagenomics is a powerful tool for both the discovery and development of
biocatalysts. This study presents the high-throughput functional screening of 22 large-insert …

Metabolic chemical reporters (MCRs) of protein glycosylation are analogues of natural
monosaccharides that bear reactive groups, like azides and alkynes. When they are added …