More than 300 million years ago, vertebrates emerged from the vast oceans to conquer
gravity and the dry land. With this transition, new adaptations occurred that included …

The eggshell is an ancient innovation that helped the vertebrates' transition from the oceans
and gain dominion over the land. Coincident with this conquest, several new eggshell and …

Increased acidic serine aspartate-rich MEPE-associated motif (ASARM) peptides cause
mineralization defects in X-linked hypophosphatemic rickets mice (HYP) and “directly” inhibit …

The SIBLING family (small integrin‐binding ligand N‐linked glycoproteins) of mineral‐
regulating proteins, which includes matrix extracellular phosphoglycoprotein (MEPE) and …

Although recent studies have established that osteocytes function as secretory cells that
regulate phosphate metabolism, the biomolecular mechanism (s) underlying these effects …

Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the
X chromosome) and DMP1 (dentin matrix protein 1) result in X-linked hypophosphatemic …

Hyp mice having an inactivating mutation of the phosphate‐regulating gene with
homologies to endopeptidases on the X‐chromosome (Phex) gene have bones with …

Autosomal recessive hypophosphatemic rickets (ARHR), which is characterized by renal
phosphate wasting, aberrant regulation of 1α-hydroxylase activity, and rickets/osteomalacia …

The last 350 years since the publication of the first medical monograph on rickets (old
English term wrickken)(Glisson et al., 1651) have seen spectacular advances in our …

Abstract Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to
endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the …