Interactions of the thymic polypeptide hormone thymopoietin with neuronal nicotinic alpha-bungarotoxin binding sites and with muscle-type, but not ganglia-type …

RJ Lukas, T Audhya, G Goldstein, L Lucero - Molecular pharmacology, 1990 - ASPET
Studies were conducted to assess the ability of the thymic polypeptide hormone
thymopoietin (TPO) to interact with proto-typical ganglia-type or muscle-type nicotinic …

Thymopoietin, a thymic polypeptide, potently interacts at muscle and neuronal nicotinic α-bungarotoxin receptors

M Quik - Molecular Neurobiology, 1992 - Springer
Current studies suggest that several distinct populations of nicotinic acetylcholine (ACh)
receptors exist. One of these is the muscle-type nicotinic receptors with which …

[PDF][PDF] Thymopoietin, a thymic polypeptide, regulates nicotinic alpha-bungarotoxin sites in chromaffin cells in culture.

M Quik, R Afar, S Geertsen, T Audhya… - Molecular …, 1990 - Citeseer
The identity of the neuronal nicotinic cr-bungarotoxin(a-BGT) site, which appears to be
distinct from the functional nicotinic receptor, is unclear. Recent work in our laboratory has …

Thymopoietin, a Thymic Polypeptide, Specifically Interacts at Neuronal Nicotinic α‐Bungarotoxin Receptors

M Quik, R Afar, T Audhya… - Journal of …, 1989 - Wiley Online Library
α‐Bungarotoxin (α‐BGT), a snake venom polypeptide, interacts potently and specifically with
a nicotinic receptor population in neuronal tissue. However, the identity of this site is unclear …

Calcium-dependent effect of the thymic polypeptide thymopoietin on the desensitization of the nicotinic acetylcholine receptor.

F Revah, C Mulle, C Pinset, T Audhya… - Proceedings of the …, 1987 - National Acad Sciences
The effects of the thymic polypeptide thymopoietin (Tpo) on the properties of the nicotinic
acetylcholine receptor (AcChoR) were investigated by patch clamp techniques on mouse C2 …

Evidence for thymopoietin and thymopoietin/alpha-bungarotoxin/nicotinic receptors within the brain.

M Quik, U Babu, T Audhya… - Proceedings of the …, 1991 - National Acad Sciences
Thymopoietin, a polypeptide hormone of the thymus that has pleiotropic actions on the
immune, endocrine, and nervous systems, potently interacts with the neuromuscular …

Thymopoietin, a polypeptide ligand for the α-bungarotoxin binding site in brain: an autoradiographic study

R Afar, PBS Clarke, G Goldstein, M Quik - Neuroscience, 1992 - Elsevier
Abstract Thymopoietin, a 48–49-amino acid polypeptide present in the thymus gland, was
investigated as a potential ligand for the neuronal nicotinic α-bungarotoxin binding site in rat …

Binding of thymopoietin to the acetylcholine receptor.

K Venkatasubramanian, T Audhya… - Proceedings of the …, 1986 - National Acad Sciences
Thymopoietin is a polypeptide hormone of the thymus with physiological effects on the
immune system and on acetylcholine-mediated transmission at the neuromuscular synapse …

Thymopoietin inhibits function and ligand binding to nicotinic receptors at the neuromuscular junction.

M Quik, B Collier, T Audhya, G Goldstein - Journal of Pharmacology and …, 1990 - ASPET
Thymopoietin is a 48 to 49 amino acid polypeptide hormone of the thymus, which regulates
immune function. The present experiments show that the polypeptide can cause a complete …

Thymopoietin, a potent antagonist at nicotinic receptors in C2 muscle cell cultures.

M Quik, H El-Bizri, T Audhya, G Goldstein - Molecular pharmacology, 1991 - ASPET
Recent work has shown that thymopoietin, a polypeptide with actions in the immune and
nervous systems, potently binds to the alpha-bungarotoxin (alpha-BGT) receptor. The …