PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT signaling pathway in non-small cell lung cancer

Y Kong, R Jiang, H Zhou, M Ge, H Lin, Y Wang… - Journal of Translational …, 2024 - Springer
Background Lung cancer stands as the second most prevalent malignant neoplasm
worldwide. Addressing the underlying mechanisms propelling the progression of non-small …

PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing

S Mao, Y Li, Z Lu, Y Che, J Huang, Y Lei… - Cancer …, 2019 - Wiley Online Library
Alternative splicing (AS) and the regulation of AS by splicing factors play critical roles in
cancer. Plant homeodomain (PHD)–finger domain protein PHF5A, a critical splicing factor …

PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma

Y Yang, J Zhu, T Zhang, J Liu, Y Li, Y Zhu, L Xu… - Journal of Experimental …, 2018 - Springer
Background PHD-finger domain protein 5A (PHF5A) is a highly conserved small
transcriptional regulator also involved in pre-mRNA splicing; however, its biological …

PHF5A contributes to the maintenance of the cancer stem-like phenotype in non-small cell lung cancer by regulating histone deacetylase 8

Y Yang, M Li, X Zhou, W Wang, Y Shao… - Annals of Clinical & …, 2022 - Assoc Clin Scientists
Objective. Cancer stem-like cells (CSLCs) are closely associated with tumor recurrence,
metastasis, and drug-resistance. PHD-finger domain protein 5A (PHF5A) is related to …

[HTML][HTML] FHL2 activates β-catenin/Wnt signaling by complexing with APC and TRIM63 in lung adenocarcinoma

J Gao, YQ Ao, J Deng, M Lin, S Wang, JH Jiang… - Translational …, 2024 - Elsevier
Objectives Four and a half LIM domain 2 protein (FHL2) was reported to regulate the
progression of various cancers and this study aimed to clarify the intrinsic mechanism of …

PHF5A Promotes Proliferation and Migration of Non-Small Cell Lung Cancer by Regulating of PI3K/AKT Pathway

H Wang, F Liu, C Bai, N Xu - Zhongguo fei ai za zhi= Chinese …, 2023 - europepmc.org
Background There have been many significant advances in the diagnosis and treatment of
non-small cell lung cancer (NSCLC). However, the mechanism underlying the progression …

HIF1A/PCDH7 axis mediates fatty acid synthesis and metabolism to inhibit lung adenocarcinoma anoikis

X Yang, Q Zhang, L Wei, K Liu - Journal of Biochemical and …, 2024 - Wiley Online Library
Background Aberrantly expressed PCDH7 participates in the malignant progression of many
cancers. PCDH7 has been newly discovered as a risk factor in lung cancer, but its functional …

Comprehensive analysis of PHF5A as a potential prognostic biomarker and therapeutic target across cancers and in hepatocellular carcinoma

Q Cheng, W Ji, Z Lv, W Wang, Z Xu, S Chen, W Zhang… - BMC cancer, 2024 - Springer
Objective Cancer is a predominant cause of death globally. PHD-finger domain protein 5 A
(PHF5A) has been reported to participate in various cancers; however, there has been no …

A novel function of HRP‐3 in regulating cell cycle progression via the HDAC–E2F1–Cyclin E pathway in lung cancer

HS Yun, J Lee, JY Kim, YJ Sim, CW Lee… - Cancer …, 2022 - Wiley Online Library
To improve the poor survival rate of lung cancer patients, we investigated the role of HDGF‐
related protein 3 (HRP‐3) as a potential biomarker for lung cancer. The expression of …

[HTML][HTML] Promotion of non-small cell lung cancer tumor growth by FHL2 via inducing angiogenesis and vascular permeability

T Chen, J Chen, Q Chen, Z Liang, L Pan… - Journal of Thoracic …, 2024 - ncbi.nlm.nih.gov
Background Antiangiogenetic therapy is one of the effective strategies for non-small cell
lung cancer (NSCLC) treatment. Four-and-a-half LIM-domain protein 2 (FHL2) serves as a …