Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong
association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the …

Spondyloarthropathies (SpA) are a group of chronic rheumatic diseases, which show a
strong asoociation with human leukocyte antigen (HLA)-B27. Although the association …

Nearly four decades have passed since two groups first reported the remarkable
relationship between HLA B27 and ankylosing spondylitis 1, 2. This is arguably the …

Although the influence of HLA-B27 on the development of spondyloarthropathies is
undisputed, its role in pathogenesis remains unclear. New ideas have focused on abnormal …

HLA-B27: is the strongest HLA molecule associated with a disease. However, the reason
only a small fraction of HLA-B27 positive individuals develop spondyloarthropathies is still …

Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly
associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown …

HLA-B27 is a risk factor closely associated to spondyloarthropathies (SpA). One form of SpA
is reactive arthritis (ReA), which develops as a complication after certain bacterial infections …

This article summarizes the proceedings of a one-day international workshop held in July
2009 on the role of HLA-B27 in the pathogenesis of ankylosing spondylitis (AS) and related …

The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the
intriguing models that could exist between a molecule and human disease in medicine …

Compelling evidence indicates that HLA-B27 is directly involved in the etiopathogenesis of
the spondyloarthropathies (SpAs). Several hypotheses based on its native antigenic …