Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …

Molecular characterization of genome-wide association study (GWAS) loci can uncover key
genes and biological mechanisms underpinning complex traits and diseases. Here we …

Prostate cancer is the second most common cancer in men worldwide. Over the past
decade, large-scale integrative genomics efforts have enhanced our understanding of this …

Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how
these interact to produce the molecular phenotypes of tumors. We therefore quantified the …

Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …

Abstract The Androgen Receptor (AR) is the key-driving transcription factor in prostate
cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has …

Prostate cancer development involves corruption of the normal prostate transcriptional
network, following deregulated expression or mutation of key transcription factors. Here, we …

Highlights•Patients who receive antiandrogen treatments are more likely to develop
CRPC.•A genomic landscape study has identified aberrant epigenetic events in CRPC and …

Despite efforts to profile prostate cancer, the genetic alterations and biological processes
that correlate with the observed histological progression are unclear. Using laser-capture …

Master transcription factors interact with DNA to establish cell type identity and to regulate
gene expression in mammalian cells,. The genome-wide map of these transcription factor …