Lung cancer continues to be the leading cause of cancer deaths and more than one million
lung cancer patients will die every year worldwide. Radiotherapy (RT) plays an important …

Background Radiation-induced lung injury (RILI) often occurs during clinical chest
radiotherapy and acute irradiation from accidental nuclear leakage. This study explored the …

Radiation therapy is one of the primary treatments for thoracic malignancies, with radiation-
induced lung injury (RILI) emerging as its most prevalent complication. RILI encompasses …

Background The lung is sensitive to radiation, increasing normal tissue toxicity risks
following radiation therapy. Adverse outcomes include pneumonitis and pulmonary fibrosis …

Radiation therapy is one of the major therapeutic modalities for most solid tumors. The anti-
tumor effect of radiation therapy consists of the direct tumor cell killing, as well as the …

Purpose: Thoracic irradiation injures lung parenchyma, triggering inflammation and immune
cell activation, leading to pneumonitis and fibrosis. Macrophage polarization contributes to …

Radiation-induced lung injury (RILI) is a delayed effect of acute radiation exposure that can
limit curative cancer treatment therapies and cause lethality following high-dose whole …

Exposure of the lung to radiation produces injury and inflammatory responses that result in
microenvironmental alterations, which can promote the development of pneumonitis and/or …

Radiation therapy is an important modality in the treatment of lung cancer, but it can lead to
radiation pneumonitis, and eventually radiation fibrosis. To date, only few available drugs …

BACKGROUND AND PURPOSE: Inflammatory and fibrogenic processes play a crucial role
in the radiation-induced injury in the lung. The aim of the present study was to examine …