Cross-species comparison of drug responses at the organoid level could help to determine
the human relevance of findings from animal studies. To this end, we first need to evaluate …

Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the
small and large intestine of patients. Symptoms can be severe and lead to the interruption of …

Intestinal organoid may serve as an alternative model for toxicity testing. However, the
linkage between specific morphological alterations in organoids and chemical-induced …

Intestinal organoids are physiologically relevant tools used for cellular models. However, the
suitability of organoids to examine biological functions over existing established cell lines …

Intestinal organoids derived from LGR5+ adult stem cells allow for long-term culturing, more
closely resemble human physiology than traditional intestinal models, like Caco-2, and have …

Organoids and three-dimensional (3D) cell cultures allow the investigation of complex
biological mechanisms and regulations in vitro, which previously was not possible in …

The intestine is a complex organ formed of different types of cell distributed in different layers
of tissue. To minimize animal experiments, for decades, researchers have been trying to …

The intestine is vulnerable to chemotherapy-induced damage due to the high rate of
intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid …

In vitro models, such as primary cells and continuous cell lines routinely used for evaluating
drug candidates, have limitations in their translational relevance to human diseases …

Organoids recapitulate the (patho) physiological processes in certain tissues and organs
closer than classical cell lines. Therefore, organoid technology offers great potentials in drug …