It is generally considered that eumelanin (EM) is photoprotective while pheomelanin (PM) is
phototoxic. A recent study using a mouse model demonstrated that PM produces reactive …

Eumelanin is photoprotective while pheomelanin is phototoxic to pigmented tissues.
Ultraviolet A (UVA)‐induced tanning seems to result from the photooxidation of pre‐existing …

Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-
catalyzed oxidation of tyrosine in presence of cysteine. Generally, the formation of melanin …

Eumelanin is photoprotective for pigmented tissues while pheomelanin is phototoxic. In this
review, we summarize current understanding of how eumelanin and pheomelanin structures …

Melanins are thought to be important modulators of photochemistry in skin. Eumelanin, a
black-brown pigment, is believed to protect against UV-induced photodamage, whereas …

The abnormal susceptibility of red‐haired individuals to UV‐induced inflammation and skin
cancers is commonly attributed to the marked photoreactivity of pheomelanin pigments …

Although melanin is a photoprotective pigment, its elevated photochemical reactivity could
lead to various phototoxic processes. Photoreactivity of synthetic pheomelanin, derived from …

The purpose of this investigation was to study the ultraviolet A-induced effects on melanin
pigmentation both in an in vitro model system and in vivo. Ultraviolet-Vis absorbance spectra …

Melanin is the main pigment in animal skin. It is a heterogeneous polyphenolic molecule
with a generalized absorption in the UV− visible range synthesized in melanocytes, a kind of …

Pheomelanin has been implicated in the increased susceptibility to UV-induced melanoma
for people with light skin and red hair. Recent studies identified a UV-independent pathway …