Human cytochromes P450 in health and disease
There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …
Human cytochromes P450: problems and prospects
FJ Gonzalez - Trends in pharmacological sciences, 1992 - cell.com
Cyfockromes? 450 are a supe~ amily of haem-containing monoo~ genases. In mammals,
&too general ckzsses of P45Os exisf: six families involved in sfero'Oid and bile acid …
&too general ckzsses of P45Os exisf: six families involved in sfero'Oid and bile acid …
The human genome project and novel aspects of cytochrome P450 research
M Ingelman-Sundberg - Toxicology and applied pharmacology, 2005 - Elsevier
Currently, 57 active cytochrome P450 (CYP) genes and 58 pseudogenes are known to be
present in the human genome. Among the genes discovered by initiatives in the human …
present in the human genome. Among the genes discovered by initiatives in the human …
The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks
N Plant - Biochimica et Biophysica Acta (BBA)-General Subjects, 2007 - Elsevier
The Cytochrome P450 super-family is a fundamental requirement for the viability of most life,
with Cytochrome P450 proteins having been identified in organisms ranging from bacteria to …
with Cytochrome P450 proteins having been identified in organisms ranging from bacteria to …
Clinical importance of the cytochromes P450
DW Nebert, DW Russell - The Lancet, 2002 - thelancet.com
The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …
Human cytochromes P450
JA Hasler, R Estabrook, M Murray, I Pikuleva… - Molecular aspects of …, 1999 - Elsevier
The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from
expression of a gene super-family that currently contains around 1000 members in species …
expression of a gene super-family that currently contains around 1000 members in species …
A passion for P450s (remembrances of the early history of research on cytochrome P450)
RW Estabrook - Drug metabolism and disposition, 2003 - ASPET
Many members of the superfamily of hemeproteins, known as cytochrome P450 (P450 or
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …
The central role of cytochrome P450 in xenobiotic metabolism—a brief review on a fascinating enzyme family
F Esteves, J Rueff, M Kranendonk - Journal of xenobiotics, 2021 - mdpi.com
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
hemoproteins that are responsible for the metabolism of a wide variety of clinically …
A world of cytochrome P450s
DR Nelson - … Transactions of the Royal Society B …, 2013 - royalsocietypublishing.org
The world we live in is a biosphere influenced by all organisms who inhabit it. It is also an
ecology of genes, with some having rather startling effects. The premise put forth in this …
ecology of genes, with some having rather startling effects. The premise put forth in this …
57 varieties: the human cytochromes P450
DFV Lewis - Pharmacogenomics, 2004 - Taylor & Francis
The human cytochrome P450 (CYP) complement of heme-thiolate enzymes is reviewed. Of
the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that …
the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that …