Human cytochromes P450 in health and disease

DW Nebert, K Wikvall, WL Miller - … Transactions of the …, 2013 - royalsocietypublishing.org
There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …

Human cytochromes P450: problems and prospects

FJ Gonzalez - Trends in pharmacological sciences, 1992 - cell.com
Cyfockromes? 450 are a supe~ amily of haem-containing monoo~ genases. In mammals,
&too general ckzsses of P45Os exisf: six families involved in sfero'Oid and bile acid …

The human genome project and novel aspects of cytochrome P450 research

M Ingelman-Sundberg - Toxicology and applied pharmacology, 2005 - Elsevier
Currently, 57 active cytochrome P450 (CYP) genes and 58 pseudogenes are known to be
present in the human genome. Among the genes discovered by initiatives in the human …

The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks

N Plant - Biochimica et Biophysica Acta (BBA)-General Subjects, 2007 - Elsevier
The Cytochrome P450 super-family is a fundamental requirement for the viability of most life,
with Cytochrome P450 proteins having been identified in organisms ranging from bacteria to …

Clinical importance of the cytochromes P450

DW Nebert, DW Russell - The Lancet, 2002 - thelancet.com
The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …

Human cytochromes P450

JA Hasler, R Estabrook, M Murray, I Pikuleva… - Molecular aspects of …, 1999 - Elsevier
The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from
expression of a gene super-family that currently contains around 1000 members in species …

A passion for P450s (remembrances of the early history of research on cytochrome P450)

RW Estabrook - Drug metabolism and disposition, 2003 - ASPET
Many members of the superfamily of hemeproteins, known as cytochrome P450 (P450 or
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …

The central role of cytochrome P450 in xenobiotic metabolism—a brief review on a fascinating enzyme family

F Esteves, J Rueff, M Kranendonk - Journal of xenobiotics, 2021 - mdpi.com
Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

A world of cytochrome P450s

DR Nelson - … Transactions of the Royal Society B …, 2013 - royalsocietypublishing.org
The world we live in is a biosphere influenced by all organisms who inhabit it. It is also an
ecology of genes, with some having rather startling effects. The premise put forth in this …

57 varieties: the human cytochromes P450

DFV Lewis - Pharmacogenomics, 2004 - Taylor & Francis
The human cytochrome P450 (CYP) complement of heme-thiolate enzymes is reviewed. Of
the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that …