CD8+ T cell longevity regulated by metabolic activity plays important roles in cancer
immunotherapy. Although in vitro–polarized, transferred IL-9–secreting CD8+ Tc9 (cytotoxic …

T-cell-based therapies represent a promising strategy for cancer treatment. In this context,
cytokines are discussed as a bona fide instrument for fine-tuning T-cell biology. One …

Memory CD8 T cells can provide long-term protection against tumors, which depends on
their enhanced proliferative capacity, self-renewal and unique metabolic rewiring to sustain …

The functional state of T cells is a key determinant for effective antitumor immunity and
immunotherapy. Cellular metabolism, including lipid metabolism, controls T cell …

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising novel
therapeutic approach. However, primary and secondary resistance to CAR-T cell therapy is …

Heightened effector function and prolonged persistence, the key attributes of Th1 and Th17
cells, respectively, are key features of potent anti-tumor T cells. Here, we established ex vivo …

Accumulating evidence suggests the immunosuppressive microenvironments created by
malignant tumors represent a major obstacle for effective anti‐tumor immunity. A better …

Improvements in the quality and fitness of chimeric antigen receptor (CAR)-engineered T
cells, through CAR design or manufacturing optimizations, could enhance the therapeutic …

Depleting regulatory T cells (Treg cells) to counteract immunosuppressive features of the
tumor microenvironment (TME) is an attractive strategy for cancer treatment; however …

Metabolic reprogramming dictates the fate and function of stimulated T cells, yet these
pathways can be suppressed in T cells in tumor microenvironments. We previously showed …