BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells
H Seo, E González-Avalos, W Zhang… - Nature …, 2021 - nature.com
The transcription factors nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-
1; Fos–Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence …
1; Fos–Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence …
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells
Chimeric antigen receptor (CAR) T cell therapy has limited efficacy against solid tumors, and
one major challenge is T cell exhaustion. To address this challenge, we performed a …
one major challenge is T cell exhaustion. To address this challenge, we performed a …
c-Jun overexpression in CAR T cells induces exhaustion resistance
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of
patients with cancer,–, but dysfunction due to T cell exhaustion is an important barrier to …
patients with cancer,–, but dysfunction due to T cell exhaustion is an important barrier to …
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive
therapeutic efficacy against leukemias and lymphomas. However, they have not been as …
therapeutic efficacy against leukemias and lymphomas. However, they have not been as …
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells
During persistent antigen stimulation, CD8+ T cells show a gradual decrease in effector
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
TET2 guards against unchecked BATF3-induced CAR T cell expansion
Further advances in cell engineering are needed to increase the efficacy of chimeric antigen
receptor (CAR) and other T cell-based therapies,,,–. As T cell differentiation and functional …
receptor (CAR) and other T cell-based therapies,,,–. As T cell differentiation and functional …
BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors
K Itahashi, T Irie, J Yuda, S Kumagai… - Science …, 2022 - science.org
Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts,
thereby becoming promising targets in cancer immunotherapy. Despite the importance of …
thereby becoming promising targets in cancer immunotherapy. Despite the importance of …
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion
M Rangachari, C Zhu, K Sakuishi, S Xiao, J Karman… - Nature medicine, 2012 - nature.com
T cell immunoglobulin and mucin domain–containing 3 (Tim-3) is an inhibitory receptor that
is expressed on exhausted T cells during infection with HIV-1 and hepatitis C virus. By …
is expressed on exhausted T cells during infection with HIV-1 and hepatitis C virus. By …
Transcription factor IRF4 promotes CD8+ T cell exhaustion and limits the development of memory-like T cells during chronic infection
During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by
expression of inhibitory receptors, down-modulation of effector function, and metabolic …
expression of inhibitory receptors, down-modulation of effector function, and metabolic …
Compensatory dendritic cell development mediated by BATF–IRF interactions
R Tussiwand, WL Lee, TL Murphy, M Mashayekhi… - Nature, 2012 - nature.com
The AP1 transcription factor Batf3 is required for homeostatic development of CD8α+
classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens …
classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens …