Abstract Background Dipeptidyl peptidase-3 (DPP3) is a metallopeptidase which cleaves
bioactive peptides, notably angiotensin II, and is involved in inflammation regulation. DPP3 …

Abstract Background Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the
degradation of various cardiovascular and endorphin mediators. High levels of circulating …

Introduction Septic shock remains a major health care problem worldwide. Sepsis-induced
immune alterations are thought to play a major role in patients' mortality and susceptibility to …

Introduction Protein disulfide isomerase (PDI) is an important factor for the protein
modification step in the post-translational event. PDI plays an essential role in cell survival …

Background A dysbalanced coagulation system is part of the pathological host response to
infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant …

Background Altered coagulation and alveolar injury are the hallmarks of acute respiratory
distress syndrome (ARDS). However, whether the biomarkers that reflect pathophysiology …

Introduction Biomarkers, such as C-reactive protein [CRP] and procalcitonin [PCT], are
insufficiently sensitive or specific to stratify patients with sepsis. We investigate the …

Introduction Non-intensive care unit (ICU) cohorts have shown an association between
inflammatory disturbances and delirium, though these relationships have not been studied …

Background Acute lung injury (ALI) is a major cause of acute respiratory failure with high
mortality despite lung-protective ventilation. Prior work has shown disordered inflammation …

Introduction It is difficult to adjust fluid balance adequately in patients with severe burns due
to various physical changes. B-type natriuretic peptide (BNP) is emerging as a potential …