The risky decision-making task (RDT) measures risk-taking in a rat model by assessing
preference between a small, safe reward and a large reward with increasing risk of …

BACKGROUND: To optimize behavior, organisms evaluate the risks and benefits of
available choices. The mesolimbic dopamine (DA) system encodes information about …

The medial prefrontal cortex (mPFC) and the core region of the nucleus accumbens (AcbC)
are key regions of a neural system that subserves risk-based decision making. Here, we …

Considerable evidence has implicated dopamine (DA) signals in target regions of midbrain
DA neurons such as the medial prefrontal cortex or the core region of the nucleus …

Background: It is well known that brain dopamine (DA) signals support risk-based decision
making; however, the specific terminal regions of midbrain DA neurons through which DA …

Many psychiatric disorders are characterized by abnormal risky decision-making and
dysregulated dopamine receptor expression. The current study was designed to determine …

Rationale Evaluation of risks and rewards associated with different options is facilitated by
components of the mesocorticolimbic dopamine (DA) system. Augmenting or reducing DA …

The nucleus accumbens (NAc) serves as an integral node within cortico-limbic circuitry that
regulates various forms of cost–benefit decision making. The dopamine (DA) system has …

Dopamine has been associated with risky decision-making, as well as with pathological
gambling, a behavioral addiction characterized by excessive risk-taking behavior. However …

Decision-making involves frontolimbic and dopaminergic brain regions, but how prior choice
outcomes, dopamine neurotransmission, and frontostriatal activity are integrated to affect …