In the thesis I present a new method to assess longitudinally spinal cord (SC) atrophy, called
SIENA-SC. The spinal cord (SC) is an important area of the central nervous system (CNS) as …

In this work, we introduce a new pipeline based on the latest iteration of the BSI for
computing atrophy in the SC and compare its results with the most popular atrophy …

Spinal cord atrophy measurements obtained from structural magnetic resonance imaging
(MRI) are associated with disability in many neurological diseases and serve as in vivo …

Objective Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but
longitudinal assessments on magnetic resonance imaging using segmentation‐based …

Spinal cord atrophy is a common and clinically relevant feature of multiple sclerosis (MS),
and can be used to monitor disease progression and as an outcome measure in clinical …

Purpose To identify an improved method for measuring spinal cord cross‐sectional area
(CSA) using magnetic resonance imaging (MRI) in multiple sclerosis (MS). Materials and …

Spinal cord atrophy is a clinically-relevant feature of multiple sclerosis (MS), but can be
difficult to estimate longitudinally using segmentation-based methods. We applied a fully …

Background: Atrophy measurements obtained from structural MRI are useful biomarkers of
neurodegeneration. Spinal cord atrophy in multiple sclerosis (MS) has been shown to …

Background We aimed to evaluate the implications for clinical trial design of the generalised
boundary-shift integral (GBSI) for spinal cord atrophy measurement. Methods We included …

Objective: To perform a systematic review and meta-analysis of spinal cord (SC) atrophy in
multiple sclerosis (MS). Background: SC atrophy is emerging as an important imaging …