Mosaic RASopathies are a heterogeneous group of diseases characterized by the presence
at birth or early onset of congenital anomalies, cutaneous and vascular anomalies …

“RASopathies” are a group of developmental syndromes with partly overlapping clinical
symptoms that are caused by germline mutations of genes within the Ras/MAPK signaling …

The Ras/mitogen activated protein kinase (MAPK) pathway is essential in the regulation of
the cell cycle, differentiation, growth and cell senescence, all of which are critical to normal …

Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK)
cascade underlies the RASopathies, a family of clinically related disorders affecting …

The RASopathies are defined as a group of medical genetics syndromes that are caused by
germ-line mutations in genes that encode components or regulators of the Ras/mitogen …

RASopathies refers to the group of disorders which are caused by a mutation in various
genes of the RAS/MAPK (RAT sarcoma virus/Mitogen activated protein kinase) pathway. It …

This report summarizes and highlights the fifth International RASopathies Symposium: When
Development and Cancer Intersect, held in Orlando, Florida in July 2017. The RASopathies …

Constitutional overactivation at various levels of the RAS–MAPK pathway causes
overlapping syndromes, comprising characteristic facial features, cardiac defects, cutaneous …

Our knowledge of the Ras pathway stems from experiments on the virusinduced origins of
leukemias and solid tumors that were initiated in the mid-20th century [Gross, 1951; Epstein …

Mosaic RASopathies are an emerging group of disorders characterized by mosaic or post-
zygotic activating mutations in genes of the RAS/MAPKinase signaling pathway. The …