The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

Nucleosides are the building blocks required in constructing nucleic acids. As we learned in
school, billions of combinations are possible using only four different nucleosides, and thus …

This publication contains the Review Lectures given at a joint NATO Advanced Study
Institute and a FEB S Advanced Study Course, held at Sogesta (Nr. Urbino), Italy from the …

Depending on the target enzyme with which they interact, nucleoside analogues exhibit
marked differences in their antiviral activity spectrum. The activity spectrum of those …

This article provides an overview of the field of nucleoside antiviral agents in so far as they
have some level of current interest. It considers compounds in a number of structural …

This mini-review describes the structure-activity relationships of several series of new
nucleoside analogues. It also points to the possibilities of finding new molecular …

This is the second of two invited articles reviewing the development of nucleoside analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

Among the steps in the replication cycle of human immunodeficiency virus (HIV) that are
potential targets for antiviral chemotherapy, the viral DNA polymerase or reverse …

Publisher Summary A multitude of factors affect the biological activity of nucleoside analogs
(Nu), which must be phosphorylated intracellularly by cellular or viral enzymes before …

This is the first of two invited articles reviewing the development of nucleoside-analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …