Rearing rats in isolation has been shown to be a relevant paradigm for studying early life
stress and understanding the genesis of depression and related affective disorders. Recent …

Social isolation (SI) rearing, a model of early life stress, results in profound behavioral
alterations, including increased anxiety‐like behavior, impaired sensorimotor gating and …

Isolation rearing induces various cognitive abnormalities such as reversal learning deficits
and reduced prepulse inhibition in rats. However, there are few reports in the literature on its …

Social isolation during adulthood is a frequent problem that leads to a large variety of
adverse emotional and cognitive effects. However, most of the social isolation rodent …

Social isolation of rodents (SI) elicits a variety of stress responses such as increased
aggressiveness, hyper-locomotion, and reduced susceptibility to pentobarbital. To obtain a …

The mesocorticolimbic system contains dopamine (DA)-producing neurons in the ventral
tegmental area (VTA) and their projection targets, including the medial prefrontal cortex …

The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …

The present study investigated the effects of post-weaning social isolation (SI) on
behavioural and neuroendocrine reactivity to stress of male and female rats. Innate aspects …

Chronic stress is a contributing risk factor in the development of psychiatric illnesses,
including depressive disorders. The mechanisms of their psychopathology are multifaceted …

Social isolation rearing (SI) is a model of early life stress that results in neurobiological
alterations leading to increased anxiety-like behaviors. These animals also exhibit an …