Organelle damage can cause various kidney diseases. In particular, organelle stress such
as decreased proteostatic activity in the endoplasmic reticulum (ER) and altered energy …

Organelles play important roles in maintaining cellular homeostasis. Organelle stress
responses, especially in mitochondria, endoplasmic reticula (ER), and primary cilia, are …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected syndromes
that represent a global public health challenge. Organelles play essential roles in a vast …

Kidney diseases are serious health problems affecting> 800 million individuals worldwide.
The high number of affected individuals and the severe consequences of kidney dysfunction …

Advanced multiomics analysis has revealed novel pathophysiological mechanisms in
kidney disease. In particular, proteomic and metabolomic analysis shed light on …

Chronic kidney disease (CKD) is characterized by an irreversible decrease in kidney
function and induction of various metabolic dysfunctions. Accumulated findings reveal that …

The endoplasmic reticulum (ER) plays an important role in the maintenance of protein
homeostasis through its control of the concentration, conformation, folding, and trafficking of …

Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique
tasks. Thus follows that in order to coordinate these different intracellular functions, a highly …

Cells use an exquisite network of mechanisms to maintain the integrity and functionality of
their protein components. In the endoplasmic reticulum (ER), these networks of protein …

The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic
processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and …