Complement in malaria immunity and vaccines
Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a
major global health priority, although this has proven to be immensely challenging over the …
major global health priority, although this has proven to be immensely challenging over the …
Functional antibodies and protection against blood-stage malaria
Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …
protect against malaria. However, it is unclear which antibody responses are the best …
[HTML][HTML] Beyond binding: the outcomes of antibody-dependent complement activation in human malaria
Antibody immunity against malaria is effective but non-sterile. In addition to antibody-
mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated …
mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated …
Complement in malaria: immune evasion strategies and role in protective immunity
The malaria parasite has for long been thought to escape host complement attack as a
survival strategy. However, it was only recently that complement evasion mechanisms of the …
survival strategy. However, it was only recently that complement evasion mechanisms of the …
[HTML][HTML] Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
Abstract Background Antibodies targeting Plasmodium falciparum sporozoites play a key
role in human immunity to malaria. However, antibody mechanisms that neutralize …
role in human immunity to malaria. However, antibody mechanisms that neutralize …
[HTML][HTML] Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …
the world's population at risk of Plasmodium infections. The development of an effective …
Immune responses in malaria
CA Long, F Zavala - Cold Spring Harbor …, 2017 - perspectivesinmedicine.cshlp.org
Evidence accumulated through the years clearly indicates that antiparasite immune
responses can efficiently control malaria parasite infection at all development stages, and …
responses can efficiently control malaria parasite infection at all development stages, and …
Multi-functional antibody profiling for malaria vaccine development and evaluation
Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
Immune effector mechanisms in malaria: An update focusing on human immunity
AM Moormann, CE Nixon, CS Forconi - Parasite immunology, 2019 - Wiley Online Library
The past decade has witnessed dramatic decreases in malaria‐associated mortality and
morbidity around the world. This progress has largely been due to intensified malaria control …
morbidity around the world. This progress has largely been due to intensified malaria control …
[HTML][HTML] Host-parasite interactions during Plasmodium infection: Implications for immunotherapies
P Chandley, R Ranjan, S Kumar, S Rohatgi - Frontiers in Immunology, 2023 - frontiersin.org
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …
in the developing world. Multiple environmental and host and parasite factors govern the …