Complement in malaria immunity and vaccines

L Kurtovic, MJ Boyle, DH Opi, AT Kennedy… - Immunological …, 2020 - Wiley Online Library
Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a
major global health priority, although this has proven to be immensely challenging over the …

Functional antibodies and protection against blood-stage malaria

A Teo, G Feng, GV Brown, JG Beeson… - Trends in …, 2016 - cell.com
Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …

[HTML][HTML] Beyond binding: the outcomes of antibody-dependent complement activation in human malaria

D Rathnayake, EH Aitken, SJ Rogerson - Frontiers in Immunology, 2021 - frontiersin.org
Antibody immunity against malaria is effective but non-sterile. In addition to antibody-
mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated …

Complement in malaria: immune evasion strategies and role in protective immunity

PK Kiyuka, S Meri, A Khattab - FEBS letters, 2020 - Wiley Online Library
The malaria parasite has for long been thought to escape host complement attack as a
survival strategy. However, it was only recently that complement evasion mechanisms of the …

[HTML][HTML] Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

L Kurtovic, MC Behet, G Feng, L Reiling, K Chelimo… - BMC medicine, 2018 - Springer
Abstract Background Antibodies targeting Plasmodium falciparum sporozoites play a key
role in human immunity to malaria. However, antibody mechanisms that neutralize …

[HTML][HTML] Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Immune responses in malaria

CA Long, F Zavala - Cold Spring Harbor …, 2017 - perspectivesinmedicine.cshlp.org
Evidence accumulated through the years clearly indicates that antiparasite immune
responses can efficiently control malaria parasite infection at all development stages, and …

Multi-functional antibody profiling for malaria vaccine development and evaluation

DH Opi, L Kurtovic, JA Chan, JL Horton… - Expert Review of …, 2021 - Taylor & Francis
Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …

Immune effector mechanisms in malaria: An update focusing on human immunity

AM Moormann, CE Nixon, CS Forconi - Parasite immunology, 2019 - Wiley Online Library
The past decade has witnessed dramatic decreases in malaria‐associated mortality and
morbidity around the world. This progress has largely been due to intensified malaria control …

[HTML][HTML] Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

P Chandley, R Ranjan, S Kumar, S Rohatgi - Frontiers in Immunology, 2023 - frontiersin.org
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …