Background: Calcification of the aortic valve leads to increased leaflet stiffness and
consequently to the development of calcific aortic valve disease. However, the underlying …

Calcific aortic valve disease (CAVD) accompanies inflammatory cell infiltration, fibrosis, and
ultimately calcification of the valve leaflets. We previously demonstrated that dipeptidyl …

Aims The morbidity and mortality rates of calcific aortic valve disease (CAVD) remain high
while treatment options are limited. Here, we evaluated the role and therapeutic value of …

Calcific aortic valve stenosis (CAS) is the most frequent heart valve disease in the elderly,
accompanied by valve calcification. Tumor necrosis factor-α (TNF-α), a pleiotropic cytokine …

Objective—The activation of valve interstitial cells (VICs) toward an osteogenic phenotype
characterizes aortic valve sclerosis, the early asymptomatic phase of calcific aortic valve …

Objective—Calcific aortic valve disease is associated with the differentiation of valvular
interstitial cells (VICs) to myofibroblast and osteoblast-like cells, particularly in the fibrosa …

Objective—Calcific aortic valve (AoV) disease is a significant clinical problem for which the
regulatory mechanisms are poorly understood. Enhanced cell–cell adhesion is a common …

Objective To evaluate whether the use of dipeptidyl peptidase-4 (DPP-4) inhibitors and their
cardiac tissue distribution profile and anticalcification abilities are associated with risk of …

Objective—To test the hypothesis that valvular calcium deposition, pro-osteogenic signaling,
and function can be altered in mice with advanced aortic valve disease. Methods and …

Calcific Aortic Valve Disease (CAVD) is the most common heart valve disease and its
incidence is expected to rise with aging population. No medical treatment so far has shown …