A metastasis map of human cancer cell lines
Most deaths from cancer are explained by metastasis, and yet large-scale metastasis
research has been impractical owing to the complexity of in vivo models. Here we introduce …
research has been impractical owing to the complexity of in vivo models. Here we introduce …
Road map to metastasis
LJ Van't Veer, B Weigelt - Nature medicine, 2003 - nature.com
When do cancer cells acquire metastatic identity? Recent reports have indicated that the
propensity to metastasize might be hardwired early during tumor development. Now it …
propensity to metastasize might be hardwired early during tumor development. Now it …
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
Despite major advances in understanding the molecular and genetic basis of cancer,
metastasis remains the cause of> 90% of cancer-related mortality. Understanding …
metastasis remains the cause of> 90% of cancer-related mortality. Understanding …
Genes that mediate breast cancer metastasis to lung
By means of in vivo selection, transcriptomic analysis, functional verification and clinical
validation, here we identify a set of genes that marks and mediates breast cancer metastasis …
validation, here we identify a set of genes that marks and mediates breast cancer metastasis …
A molecular signature of metastasis in primary solid tumors
Metastasis is the principal event leading to death in individuals with cancer, yet its molecular
basis is poorly understood 1. To explore the molecular differences between human primary …
basis is poorly understood 1. To explore the molecular differences between human primary …
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma
Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality.
To identify genomic alterations that promote brain metastases, we performed whole-exome …
To identify genomic alterations that promote brain metastases, we performed whole-exome …
Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data
Cell lines are widely-used models to study metastatic cancer although the extent to which
they recapitulate the disease in patients remains unknown. The recent accumulation of …
they recapitulate the disease in patients remains unknown. The recent accumulation of …
Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
INTRODUCTION Cancer progression is fundamentally an evolutionary process, involving
multiple distinct steps from oncogenic transformation to metastatic dissemination to …
multiple distinct steps from oncogenic transformation to metastatic dissemination to …
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers
MQ McCreery, KD Halliwill, D Chin, R Delrosario… - Nature medicine, 2015 - nature.com
Human tumors show a high level of genetic heterogeneity, but the processes that influence
the timing and route of metastatic dissemination of the subclones are unknown. Here we …
the timing and route of metastatic dissemination of the subclones are unknown. Here we …
Pan-cancer whole-genome analyses of metastatic solid tumours
Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …
better understanding of the characteristics of late-stage cancer is required to help adapt …