Most deaths from cancer are explained by metastasis, and yet large-scale metastasis
research has been impractical owing to the complexity of in vivo models. Here we introduce …

When do cancer cells acquire metastatic identity? Recent reports have indicated that the
propensity to metastasize might be hardwired early during tumor development. Now it …

Despite major advances in understanding the molecular and genetic basis of cancer,
metastasis remains the cause of> 90% of cancer-related mortality. Understanding …

By means of in vivo selection, transcriptomic analysis, functional verification and clinical
validation, here we identify a set of genes that marks and mediates breast cancer metastasis …

Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality.
To identify genomic alterations that promote brain metastases, we performed whole-exome …

Cell lines are widely-used models to study metastatic cancer although the extent to which
they recapitulate the disease in patients remains unknown. The recent accumulation of …

INTRODUCTION Cancer progression is fundamentally an evolutionary process, involving
multiple distinct steps from oncogenic transformation to metastatic dissemination to …

Human tumors show a high level of genetic heterogeneity, but the processes that influence
the timing and route of metastatic dissemination of the subclones are unknown. Here we …

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …

Metastasis requires cancer cells to undergo metabolic changes that are poorly understood,–
. Here we show that metabolic differences among melanoma cells confer differences in …