Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …
progression are being increasingly defined. The TRACERx Renal studies and others that …
[HTML][HTML] Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA …
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA …
[HTML][HTML] Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
The genetic landscape of clear cell renal cell carcinoma (ccRCC) had been investigated
extensively but its evolution patterns remained unclear. Here we analyze the clonal …
extensively but its evolution patterns remained unclear. Here we analyze the clonal …
Current landscape of genomic biomarkers in clear cell renal cell carcinoma
Context Dramatic gains in our understanding of the molecular biology of clear cell renal cell
carcinoma (ccRCC) have created a foundation for clinical translation to improve patient care …
carcinoma (ccRCC) have created a foundation for clinical translation to improve patient care …
Chromosome 3p loss–orchestrated VHL, HIF, and epigenetic deregulation in clear cell renal cell carcinoma
JJ Hsieh, VH Le, T Oyama, CJ Ricketts… - Journal of Clinical …, 2018 - ascopubs.org
Clear cell renal cell carcinoma (ccRCC) is the most common renal cell carcinoma subtype,
and metastatic ccRCC is associated with 5-year survival rates of 10% to 20%. Genetically …
and metastatic ccRCC is associated with 5-year survival rates of 10% to 20%. Genetically …
[HTML][HTML] Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx renal
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short
arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole …
arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole …
[HTML][HTML] Updates on immunotherapy and immune landscape in renal clear cell carcinoma
Simple Summary Clear cell renal cell carcinomas (ccRCC) have several distinct
immunological features, including a high degree of immune infiltration and relatively low …
immunological features, including a high degree of immune infiltration and relatively low …
Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine
F Audenet, DR Yates, G Cancel‐Tassin… - BJU …, 2012 - Wiley Online Library
What's known on the subject? and What does the study add? Sporadic clear cell Renal Cell
Carcinoma (ccRCC) is dominated by nutations of the VHL gene located on chromosome 3p …
Carcinoma (ccRCC) is dominated by nutations of the VHL gene located on chromosome 3p …
Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma
BACKGROUND: Historically, VHL was the only frequently mutated gene in clear cell renal
cell carcinoma (ccRCC), with conflicting clinical relevance. Recent sequencing efforts have …
cell carcinoma (ccRCC), with conflicting clinical relevance. Recent sequencing efforts have …
Molecular genetics of clear-cell renal cell carcinoma
J Brugarolas - Journal of clinical oncology, 2014 - ascopubs.org
Renal cell carcinoma of clear-cell type (ccRCC) is an enigmatic tumor type, characterized by
frequent inactivation of the VHL gene (infrequently mutated in other tumor types) …
frequent inactivation of the VHL gene (infrequently mutated in other tumor types) …